If you want to discover your genetic history and where you came from... you’ve found the right place!


review of scientific and news articles on dna testing and popular genetics

Abraham's Children: A Review

Thursday, August 26, 2010

Implications for Jewish History and Genealogy

Article:  Gil Atzmon et al., “Abraham’s Children in the Genome Era:  Major Jewish Diaspora Populations Comprise Distinct Genetic Clusters with Shared Middle Eastern Ancestry,” The American Journal of Human Genetics 86 (June 11, 2010) 850-859.

This blog posting attempts to summarize this important article and translate its technical results into layman’s language for the sake of our customers. From the genetic evidence, we hope to glean some useful information about Jewish history and genealogy, especially for those who find they have “some” Jewish ancestry in their family tree but who are non-Jewish in the way they identify.

The eleven authors represent a stellar team of international researchers specializing in population genetics. The institutions involved are leading centers of genetics and biomedicine, starting with the Albert Einstein College of Medicine in New York and including Tel-Aviv University in Israel. Appearance in the American Journal of Human Genetics, a publication of the American Society of Human Genetics, assures prestige and finality of the highest order.

The study uses a new sample of 237 carefully qualified Jewish subjects, which it compares with data from the Human Genome Diversity Project started at Stanford in the 1990s, as well as the Population Reference Sample (PopRes) project, containing hundreds of thousands of SNPs (single nucleotide polymorphisms, used to differentiate genes that show heredity lines and disease linkage in populations).

The scale of the project is colossal, and it must have taken years to complete. Financial support came from private and public sources, including the U.S.-Israel Binational Science Foundation and NIH. It supersedes (while it confirms or clarifies) the two types of previous approaches to the problem: 1) genetics studies on blood groups from the 1970s, and 2) recent studies of Y chromosomal and mitochondrial haplotypes. The latter “uniparental” studies could only offer a limited view of the subject. This study uses autosomal DNA to its full advantage. The scientists had supercomputers and the latest tools in biostatistics at their disposal.

Material and Methods

The two cornerstones of any statistical study are reliability and validity. Experts would be challenged to find anything wrong with the reliability of “Abraham’s Children.” State-of-the-science genotyping, phylogeny, bootstrapping and GERMLINE algorithms are employed. But validity issues may be mentioned as likely to call some of the findings into slight question in some areas. Subjects were recruited in New York (Iranian, Iraqi, Syrian and Ashkenazi Jews), Seattle (Turkish Sephardic Jews), Greece (Greek Sephardic Jews) and Rome (Italian Jews). The main divisions into Italian, Ashkenazi, Syrian, Middle Eastern (termed Mizrahi, or Eastern, Jews here) can be seen in some instances to be question-begging, and there are equivocations in labels that might, conceivably, create “desired results.” Moreover, subjects “were included only if all four grandparents came from the same Jewish community.” Such a rule might have influenced one of the findings, namely, that “Jewish Communities Show High Levels of IBD,” or Informative By Descent shared segments of DNA (p. 855f.).

Notably, the conclusion that Ashkenazi Jews are highly inbred, with most being as close as 3rd or 4th cousins to each other, could be an effect of the sample selection from New York Ashkenazi Jews, who often emigrated together and belonged to the same synagogue for several generations. A larger, more randomized selection would have been better. The total number of Ashkenazi Jews used was only 34 persons.

Jews now living in Rome are not the same as Roman Jews. Traditional schemes of Jewry speak of the Romaniot Jews, but these were traditionally at home in the Byzantine Empire. Are Syrian Jews mostly Middle Eastern or are they another amalgam of émigrés and remnants? Where are Central Asian Jews like the large Uzbekistani population my local barber represents? The absence of Caucasian and Central Asian Jews may have affected the study’s rather resounding, over-confidant statement that it “refutes” the contention that Ashkenazi Jews have little Middle Eastern heritage and rather more of a contribution to their genetics from Khazars and Slavs. The study, like many, seems at pains to prove Middle Eastern connections of Ashkenazi Jews, who are the leading force in present-day Israel.

There are no German, Dutch, Spanish, Portuguese or English Jews in the study. “Ashkenazi” seems to represent Jews living in New York with rather uniform ancestry in Poland, Hungary, Ukraine, Lithuania and Russia. All Jews in the study seem to be of the “go to temple” (at least on the High Holy Days) sort, although no mention is made of religious orientation. Subjects were chosen because of their ostensibly “pure” Jewish roots.

Ashkenazi Jews at Yom Kippur in 19th century Central Europe from a painting by Gottlieb.

Seven Jewish population clusters are defined: 

  1. Irani Jews
  2. Iraqi Jews
  3. Syrian Jews
  4. Ashkenazi Jews
  5. Italian Jews
  6. Greek Jews
  7. Turkish Jews

These were sorted out into three major groups of the Jewish Diaspora:

  • Eastern European Ashkenazim
  • Italian, Greek and Turkish Sephardim
  • Iranian, Iraqi and Syrian Middle Easterners

How Different are Jews from Each Other? From Non-Jewish Populations?

Table 1 on page 853 shows Fst values, which indicate the degree of projected inbreeding within a cluster and allow one to make comparisons between clusters. If we look at the table of genetic diversity among Jews, we can pick out some of the following points of interest:

  • Ashkenazi Jews are very, very different genetically from Italian (Sephardic) Jews: genetic distance between the two populations is over 3.1, whereas that between Ashkenazi Jews and non-Jewish European populations such as Russian or French hardly ever goes above 1.0.

  • Syrian and Iraqi Jews are also very different from each other; Syrian Jews group together with European (Ashkenazi and Sephardic) Jews, a major finding of the study.

  • All Jewish populations, including Ashkenazim, resemble genetically the Druze, a Middle Eastern population that is still in its original place in Lebanon and Israel. Syrian and Turkish Jews (Sephardim) most resemble Druzes.

The study identifies two major groups of Jews, characterizing them as Middle Eastern Jews and European/Syrian Jews. Of the Middle Eastern Jews, the Irani and Iraqi were scarcely distinguishable. The Europeans have varying degrees of admixture with non-Jewish populations into which they have been dispersed. European Jews are 20-40% (or on another page, 30-60%) European, the study concludes, while Sephardic Jews have 8-11% North African (Berber) DNA. Italian, Syrian, Iranian and Iraqi Jews are the most inbred.

All these statistics “highlight the commonality of Jewish origin” and expose the Middle Eastern origins and genetic unity of Jewish people, even in dispersal from their homeland in ancient Israel.

The flipside of inbreeding is outbreeding or exogamy. If European Jews are highly admixed, by the same token, many Europeans must have some degree of Jewish admixture. Gene flow did not go just one way. What are the most outbred Jewish clusters according to the study? It is the Sephardic Jews from Italy, Greece and Turkey, with low rates of shared IBD and greater diversity than the Ashkenazim.

Lost Tribes Still Lost

 The brief Discussion section at the end of the article attempts to put the statistical findings together with an outline of Jewish history and resolve some of the mysteries of Jewish genetic makeup, chiefly the Khazar question. “Each of the Jewish populations formed its own cluster as part of the larger Jewish cluster,” the authors conclude. “Each group demonstrated Middle Eastern ancestry and variable admixture with European populations.”

Next, the authors attack the difficulty of determining when the major split between Eastern and Western Jewish groups occurred (with Syrians falling out with the Sephardim and Ashkenazim in the West, although intermediate in genetic distance with Middle Eastern Jews like the Iraqi and Irani). Based on IBD or calculations of shared genes on the front end or bottlenecks and back end or genetic drift, “a split between Middle Eastern Iraqi and Iranian Jews and European/Syrian Jews…is 100-150 generations [or] 2500 years ago.” They correlate this population divide with the Babylonian and Persian periods of Jewish history. These disturbances began in the 900s-800s BCE when the Kingdom of David fell apart into the Kingdom of Jerusalem and the Northern Kingdom (Samaria , Israel, Ephraim) and were finalized in the 6th century BCE when King Cyrus of Persia granted permission to the exiles to be repatriated from Babylon to Jerusalem.

In the shuffle, the so-called Lost Tribes representing the Northern Kingdom had been dispersed “beyond the river” into Central Asia, leaving the Judeans in the ascendancy in Israel. Although the authors do not explicity state it, the fact that Syrian Jews are several quantums’ length closer in affinity with European Jews than Middle Eastern Jews seems to reflect the historic Return to Zion and inauguration of the Second Temple in Jerusalem in 516 BCE and explain why European Jews, especially Sephardim, emphasize the House of David and Tribes of Levi in their traditional ancestral accounts. So far, the autosomal clock of change seems to beat with the march of history.


Khazar kingdom in the Middle Ages.

The article is clear about another thing, “the idea of non-Semitic Mediterranean ancestry in the formation of the European/Syrian Jewish groups,” attributing this to the mass conversions and proselytism during Greco-Roman times. It mentions that there were six million Jews in the Roman Empire, when Judaism accounted for 10% of the population. But here is where the authors’ sense of history begins to get fuzzy. They do not speak of medieval conversions or mention, for instance, the Jews of Visigothic and Berber Spain and Septimanian France and gloss over the huge Khazar conversion and expansion event, 600-1000 CE. Again, medieval history does not seem to be geneticists’ strength.

“Abraham’s Children” claims that the genetic composition of European/Syrian Jewish groups “is incompatible with theories that Ashkenazi Jews are for the most part the direct lineal descendants of converted Khazars or Slavs” (857). In this brief sentence are a number of fallacies, special pleading, misnomers, false assumptions, sleights of hand, straw arguments and equivocations. This blog  posting can only touch on the controversy, but to begin with, as we have seen, Ashkenazi Jews (n=34, all from New York) are lumped together with Sephardim and Syrian Jews as having Middle Eastern core pedigrees, even though they have the highest amount of local population admixture. Are Khazars the same as Slavs? Not ethnographically. They are sometimes treated as Middle Easterners and sometimes as Europeans or other interlopers in this article, but it doesn’t seem to matter really, because there are no Khazars in the study sample. The authors are thus stalking a phantom, which they duly track down and slay.

Ghost in the Machine

Using haplogroup studies, the authors raise the possibility of 12.5% non-Middle Eastern admixture per generation in Ashkenazi Jews (based on Hammer et al.). They also draw attention to the 7.5% frequency of haplogroup R1a1 among Ashkenazi Jews, a non-Middle Eastern, rather Eastern European male lineage. But R1a1 is not diagnostic of Khazars; try maybe G. R1a1 descendants are typically fair haired and light-eyed; Khazars had a Middle Eastern, Turkic appearance, with dark features.

In a sense, geneticists always seem to find support for what they set out to prove in the first place. It is small wonder that “Abraham’s Fathers” comes at the end of and completes a decades-long push by Big Science to legitimize Jewish claims to Middle Eastern roots. It is a splendid survey, the last in a long series, but it is not the final word on the subject. There are flaws both in the sampling and historical thinking.

The Thirteenth Tribe (1976) by Arthur Koestler, a Hungarian Ashkenazi Jewish author, advanced the thesis that the modern Jewish population in Central and Eastern Europe is not descended from the historical Israelites of antiquity, but from Khazars. This Turkic people of the Caucasus region converted to Judaism in the 8th century and moved into Russia, Hungary, Ukraine, Poland, Belarus, Lithuania and Germany during the 12th and 13th century when the Khazar Empire was collapsing. Koestler's work was founded on that of the French scholar Ernest Renan and set off a firestorm of controversy among Zionists. 




Please tell us what you think

Name, website, and email are optional; if we publish your comment, your name will be shown, and may be linked to your website if provided, but the email you enter will not be published.

Captcha Image

Recent Posts


Ziesmer, Zizmor Nature Communications far from the tree Secret History of the Cherokee Indians Myra Nichols Nancy Gentry Joel E. Harris Thuya genetic determinism Johnny Depp Lab Corp INORA Panther's Lodge Texas A&M University Helladic art ENFSI Akhenaten Mary Kugler pipe carving Hopi Indians Phillipe Charlier Bryan Sykes Etruscans Puerto Rico Abraham Lincoln Ostenaco Zizmer Applied Epistemology personal genomics Rafael Falk DNA Forums haplogroup E Black Irish Colima Les Miserables Fritz Zimmerman Russell Belk James Stritzel news university of North Carolina at Chapel Hill haplogroup N Old Souls in a New World Phyllis Starnes Middle Ages Sinti oncology Anglo-Saxons Melungeon Heritage Association population genetics DNA Fingerprint Test Anasazi National Museum of Natural History giants Jon Entine Paleolithic Age admixture Jewish novelists evolution Satoshi Horai Gunnar Thompson Jan Ravenspirit Franz medicine Colin Renfrew Family Tree DNA Ron Janke Douglas C. Wallace metis Mark Stoneking myths Barnard College Virginia DeMarce Bureau of Indian Affairs Colin Pitchfork Theodore Steinberg Marie Cheng Nephilim, Fritz Zimmerman Albert Einstein College of Medicine Teresa Panther-Yates ISOGG Tennessee Irish history Mucogee Creeks mental foramen Kentucky El Paso Jewish contribution to world literature Basques Maui Cornwall NPR Panther's Lodge Publishers autosomal DNA Indo-Europeans Jews and Muslims in British Colonial America Society for Crypto-Judaic Studies Native American DNA Test Monica Sanowar Hadassah Magazine race genetic memory Anacostia Indians Ripan Malhi Mary Settegast ancient DNA First Peoples Mark Thomas Smithsonian Institution Cleopatra Virginia genealogy Normans Moundbuilders David Reich MHC Harold Sterling Gladwin Bering Land Bridge Britain Cancer Genome Atlas Science Daily, Genome Biol. Evol., Eran Elhaik, Khazarian Hypothesis, Rhineland Hypothesis Daniel Defoe Majorca megapopulations haplogroup X Jesse Montes genealogy Rutgers University Anne C. Stone Sir Joshua Reynolds Shlomo Sand Illumina X chromosome surnames ged.com Carl Zimmer Alia Garcia-Ureste Alabama FDA mummies prehistory prehistoric art Ananya Mandal Marija Gimbutas haplogroup H French DNA powwows ethics Gustavo Ramirez Calderon Y chromosomal haplogroups Odessa Shields Cox Greeks Kari Carpenter Chris Stringer seafaring epigenetics Asiatic Fathers of America John Wilwol human leukocyte testing religion George Starr-Bresette Ashkenazi Jews Hohokam Indians Robinson Crusoe Rush Limbaugh Caucasian IntegenX phenotype Stone Age Hertfordshire DNA Diagnostics Center Rare Genes Ethel Cox Early Jews and Muslims of England and Wales (book) statistics Asiatic Echoes Cave art Philippa Langley mutation rate Micmac Indians Barack Obama Rebecca L. Cann Bradshaw Foundation Arizona State University Kari Schroeder Monya Baker Chuetas EURO DNA Fingerprint Test haplogroup T Arabic Great Goddess Gypsies Valparaiso University Melungeon Movement haplogroup W pheromones Stan Steiner Eric Wayner Ancient Giantns Who Ruled America Pueblo Grande Museum Maya Brian Wilkes Douglas Preston Peter Parham King Arthur Early Jews of England and Wales Wendell Paulson Current Anthropology African DNA Scotland private allele Miguel Gonzalez single nucleotide polymorphism DNA testing companies Horatio Cushman Stacy Schiff Neanderthals Patrick Pynes Jalisco Sorbs Central Band of Cherokee Stony Creek Baptist Church Stephen Oppenheimer Abenaki Indians Charlotte Harris Reese Nova Scotia Sea Peoples HapMap Elzina Grimwood Washington D.C. Ancestry.com N. Brent Kennedy Cajuns North Carolina M. J. Harper palatal tori Choctaw Indians Central Band of Cherokees research Tintagel gedmatch Waynesboro Pennsylvania Henry IV human migrations Gregory Mendel Chromosomal Labs Bode Technology BATWING Grim Sleeper Cherokee DNA Project Belgium Echota Cherokee Tribe of Alabama Mother Qualla Richard Lewontin District of Columbia Altai Turks Constantine Rafinesque hominids Michael Grant Chauvet cave paintings Holocaust Database Zuni Indians immunology Timothy Bestor art history B'nai Abraham Janet Lewis Crain Svante Paabo Ari Plost genetics French Canadians Sinaloa Denisovans Austro-Hungary North African DNA Amy Harmon Peter Martyr Asian DNA Old World Roots of the Cherokee Michoacan Douglas Owsley John Ruskamp haplogroup M haplogroup J haplogroup R Hohokam Keros Native American DNA Tucson Joseph Andrew Park Wilson Tom Martin Scroft Middle Eastern DNA haplogroup Z ethnic markers Richmond California Elvis Presley DNA Cooper surname Eske Willerslev Wales Comanche Indians Mexico breast cancer Bill Tiffee Pomponia Graecina clinical chemistry New York Academy of Sciences George van der Merwede Khazars American Journal of Human Genetics When Scotland Was Jewish Israel Isabel Allende King Arthur, Tintagel, The Earliest Jews and Muslims of England and Wales Pima Indians human leukocyte antigens occipital bun Daily News and Analysis 23andme Wikipedia genomics labs Kurgan Culture China linguistics Oxford Journal of Evolution Navajo William Byrd consanguinity archeology Sonora ethnicity Beringia Holocaust David Cornish Penny Ferguson Khoisan BBCNews DNA databases Bentley surname research Genie Milgrom Mildred Gentry Wendy Roth Native American Graves Protection and Repatriation Act health and medicine Bode Technology Sizemore Indians Zionism Juanita Sims Israel, Shlomo Sand Chris Tyler-Smith Rich Crankshaw Wellcome Trust Sanger Institute Iran Navajo Indians Terry Gross bloviators Melungeon Union Austronesian, Filipinos, Australoid Genex Diagnostics origins of art Finnish people Italy CODIS markers Antonio Torroni Gravettian culture London haplogroup U Richard Buckley Alec Jeffreys Walter Plecker Thruston Tablet Lithuania FBI Dienekes Anthropology Blog Henriette Mertz Indian Territory Phoenicians Phoenix Muslims in American history University of Leicester Genome Sciences Building Nikola Tesla Cherokee Freedmen Smithsonian Magazine Lebanon Patrick Henry Melanesians Bryony Jones Jack Goins Stephen A. Leon Celts DNA magazine Egyptians New Mexico Plato John Butler Joseph Jacobs Cree Indians Richard Dewhurst rapid DNA testing Roma People Epigraphic Society Romania microsatellites Promega Europe Anne Marie Fine Olmec Acadians cannibalism clan symbols haplogroup B Discovery Channel family history AP Columbia University Nayarit Slovakia education Nadia Abu El-Haj history of science Nature Genetics Victor Hugo Tifaneg Pueblo Indians Henry VII familial Mediterranean fever Solutreans Gila River Elizabeth DeLand Donald N. Yates Sizemore surname Riane Eisler haplogroup D haplogroup G Silverbell Artifacts Louis XVI Neolithic Revolution Jews American history Cismaru Kate Wong Tucson crosses Yates surname Patagonia Hawaii horizontal inheritance bar mitzvah Jewish GenWeb mitochondrial DNA Sarmatians Cohen Modal Haplotype Telltown Bulgaria DNA security Harry Ostrer Elizabeth C. Hirschman The Nation magazine Cherokee DNA Scientific American National Geographic Daily News Roberta Estes Magdalenian culture James Shoemaker Charles Perou Russia Havasupai Indians National Health Laboratories haplogroup C Richard III Discover magazine Salt River Oxford Nanopore population isolates PNAS rock art India Kitty Prince of the Bear River Athabaskans hoaxes Clovis Freemont Indians Dragging Canoe Maronites Cismar Jim Bentley Sam Kean Melungeons Leicester New York Review of Books Jewish genetics climate change DNA Fingerprint Test El Castillo cave paintings Luca Pagani Turkic DNA Irish DNA Ireland anthropology andrew solomon Cherokee Nation of Oklahoma Mohawk forensics Population genetics Algonquian Indians GlobalFiler alleles Y chromosome DNA Melba Ketchum corn polydactylism Michael Schwartz methylation Germany Kennewick Man The Calalus Texts Arabia Taino Indians Arizona Life Technologies New York Times crypto-Jews Tutankamun Science magazine haplogroup L peopling of the Americas FOX News Irish Central Sasquatch Charles Darwin Ukraine Black Dutch England Bigfoot European DNA b'nei anousim cancer Erika Chek Hayden Hispanic ancestry aliyah