If you want to discover your genetic history and where you came from... you’ve found the right place!


Review of Science Writing and News Reports on DNA Testing and Popular Genetics

Abraham's Children: A Review

Thursday, August 26, 2010

Implications for Jewish History and Genealogy

Article:  Gil Atzmon et al., “Abraham’s Children in the Genome Era:  Major Jewish Diaspora Populations Comprise Distinct Genetic Clusters with Shared Middle Eastern Ancestry,” The American Journal of Human Genetics 86 (June 11, 2010) 850-859.

This blog posting attempts to summarize this important article and translate its technical results into layman’s language for the sake of our customers. From the genetic evidence, we hope to glean some useful information about Jewish history and genealogy, especially for those who find they have “some” Jewish ancestry in their family tree but who are non-Jewish in the way they identify.

The eleven authors represent a stellar team of international researchers specializing in population genetics. The institutions involved are leading centers of genetics and biomedicine, starting with the Albert Einstein College of Medicine in New York and including Tel-Aviv University in Israel. Appearance in the American Journal of Human Genetics, a publication of the American Society of Human Genetics, assures prestige and finality of the highest order.

The study uses a new sample of 237 carefully qualified Jewish subjects, which it compares with data from the Human Genome Diversity Project started at Stanford in the 1990s, as well as the Population Reference Sample (PopRes) project, containing hundreds of thousands of SNPs (single nucleotide polymorphisms, used to differentiate genes that show heredity lines and disease linkage in populations).

The scale of the project is colossal, and it must have taken years to complete. Financial support came from private and public sources, including the U.S.-Israel Binational Science Foundation and NIH. It supersedes (while it confirms or clarifies) the two types of previous approaches to the problem: 1) genetics studies on blood groups from the 1970s, and 2) recent studies of Y chromosomal and mitochondrial haplotypes. The latter “uniparental” studies could only offer a limited view of the subject. This study uses autosomal DNA to its full advantage. The scientists had supercomputers and the latest tools in biostatistics at their disposal.

Material and Methods

The two cornerstones of any statistical study are reliability and validity. Experts would be challenged to find anything wrong with the reliability of “Abraham’s Children.” State-of-the-science genotyping, phylogeny, bootstrapping and GERMLINE algorithms are employed. But validity issues may be mentioned as likely to call some of the findings into slight question in some areas. Subjects were recruited in New York (Iranian, Iraqi, Syrian and Ashkenazi Jews), Seattle (Turkish Sephardic Jews), Greece (Greek Sephardic Jews) and Rome (Italian Jews). The main divisions into Italian, Ashkenazi, Syrian, Middle Eastern (termed Mizrahi, or Eastern, Jews here) can be seen in some instances to be question-begging, and there are equivocations in labels that might, conceivably, create “desired results.” Moreover, subjects “were included only if all four grandparents came from the same Jewish community.” Such a rule might have influenced one of the findings, namely, that “Jewish Communities Show High Levels of IBD,” or Informative By Descent shared segments of DNA (p. 855f.).

Notably, the conclusion that Ashkenazi Jews are highly inbred, with most being as close as 3rd or 4th cousins to each other, could be an effect of the sample selection from New York Ashkenazi Jews, who often emigrated together and belonged to the same synagogue for several generations. A larger, more randomized selection would have been better. The total number of Ashkenazi Jews used was only 34 persons.

Jews now living in Rome are not the same as Roman Jews. Traditional schemes of Jewry speak of the Romaniot Jews, but these were traditionally at home in the Byzantine Empire. Are Syrian Jews mostly Middle Eastern or are they another amalgam of émigrés and remnants? Where are Central Asian Jews like the large Uzbekistani population my local barber represents? The absence of Caucasian and Central Asian Jews may have affected the study’s rather resounding, over-confidant statement that it “refutes” the contention that Ashkenazi Jews have little Middle Eastern heritage and rather more of a contribution to their genetics from Khazars and Slavs. The study, like many, seems at pains to prove Middle Eastern connections of Ashkenazi Jews, who are the leading force in present-day Israel.

There are no German, Dutch, Spanish, Portuguese or English Jews in the study. “Ashkenazi” seems to represent Jews living in New York with rather uniform ancestry in Poland, Hungary, Ukraine, Lithuania and Russia. All Jews in the study seem to be of the “go to temple” (at least on the High Holy Days) sort, although no mention is made of religious orientation. Subjects were chosen because of their ostensibly “pure” Jewish roots.

Ashkenazi Jews at Yom Kippur in 19th century Central Europe from a painting by Gottlieb.

Seven Jewish population clusters are defined: 

  1. Irani Jews
  2. Iraqi Jews
  3. Syrian Jews
  4. Ashkenazi Jews
  5. Italian Jews
  6. Greek Jews
  7. Turkish Jews

These were sorted out into three major groups of the Jewish Diaspora:

  • Eastern European Ashkenazim
  • Italian, Greek and Turkish Sephardim
  • Iranian, Iraqi and Syrian Middle Easterners

How Different are Jews from Each Other? From Non-Jewish Populations?

Table 1 on page 853 shows Fst values, which indicate the degree of projected inbreeding within a cluster and allow one to make comparisons between clusters. If we look at the table of genetic diversity among Jews, we can pick out some of the following points of interest:

  • Ashkenazi Jews are very, very different genetically from Italian (Sephardic) Jews: genetic distance between the two populations is over 3.1, whereas that between Ashkenazi Jews and non-Jewish European populations such as Russian or French hardly ever goes above 1.0.

  • Syrian and Iraqi Jews are also very different from each other; Syrian Jews group together with European (Ashkenazi and Sephardic) Jews, a major finding of the study.

  • All Jewish populations, including Ashkenazim, resemble genetically the Druze, a Middle Eastern population that is still in its original place in Lebanon and Israel. Syrian and Turkish Jews (Sephardim) most resemble Druzes.

The study identifies two major groups of Jews, characterizing them as Middle Eastern Jews and European/Syrian Jews. Of the Middle Eastern Jews, the Irani and Iraqi were scarcely distinguishable. The Europeans have varying degrees of admixture with non-Jewish populations into which they have been dispersed. European Jews are 20-40% (or on another page, 30-60%) European, the study concludes, while Sephardic Jews have 8-11% North African (Berber) DNA. Italian, Syrian, Iranian and Iraqi Jews are the most inbred.

All these statistics “highlight the commonality of Jewish origin” and expose the Middle Eastern origins and genetic unity of Jewish people, even in dispersal from their homeland in ancient Israel.

The flipside of inbreeding is outbreeding or exogamy. If European Jews are highly admixed, by the same token, many Europeans must have some degree of Jewish admixture. Gene flow did not go just one way. What are the most outbred Jewish clusters according to the study? It is the Sephardic Jews from Italy, Greece and Turkey, with low rates of shared IBD and greater diversity than the Ashkenazim.

Lost Tribes Still Lost

 The brief Discussion section at the end of the article attempts to put the statistical findings together with an outline of Jewish history and resolve some of the mysteries of Jewish genetic makeup, chiefly the Khazar question. “Each of the Jewish populations formed its own cluster as part of the larger Jewish cluster,” the authors conclude. “Each group demonstrated Middle Eastern ancestry and variable admixture with European populations.”

Next, the authors attack the difficulty of determining when the major split between Eastern and Western Jewish groups occurred (with Syrians falling out with the Sephardim and Ashkenazim in the West, although intermediate in genetic distance with Middle Eastern Jews like the Iraqi and Irani). Based on IBD or calculations of shared genes on the front end or bottlenecks and back end or genetic drift, “a split between Middle Eastern Iraqi and Iranian Jews and European/Syrian Jews…is 100-150 generations [or] 2500 years ago.” They correlate this population divide with the Babylonian and Persian periods of Jewish history. These disturbances began in the 900s-800s BCE when the Kingdom of David fell apart into the Kingdom of Jerusalem and the Northern Kingdom (Samaria , Israel, Ephraim) and were finalized in the 6th century BCE when King Cyrus of Persia granted permission to the exiles to be repatriated from Babylon to Jerusalem.

In the shuffle, the so-called Lost Tribes representing the Northern Kingdom had been dispersed “beyond the river” into Central Asia, leaving the Judeans in the ascendancy in Israel. Although the authors do not explicity state it, the fact that Syrian Jews are several quantums’ length closer in affinity with European Jews than Middle Eastern Jews seems to reflect the historic Return to Zion and inauguration of the Second Temple in Jerusalem in 516 BCE and explain why European Jews, especially Sephardim, emphasize the House of David and Tribes of Levi in their traditional ancestral accounts. So far, the autosomal clock of change seems to beat with the march of history.


Khazar kingdom in the Middle Ages.

The article is clear about another thing, “the idea of non-Semitic Mediterranean ancestry in the formation of the European/Syrian Jewish groups,” attributing this to the mass conversions and proselytism during Greco-Roman times. It mentions that there were six million Jews in the Roman Empire, when Judaism accounted for 10% of the population. But here is where the authors’ sense of history begins to get fuzzy. They do not speak of medieval conversions or mention, for instance, the Jews of Visigothic and Berber Spain and Septimanian France and gloss over the huge Khazar conversion and expansion event, 600-1000 CE. Again, medieval history does not seem to be geneticists’ strength.

“Abraham’s Children” claims that the genetic composition of European/Syrian Jewish groups “is incompatible with theories that Ashkenazi Jews are for the most part the direct lineal descendants of converted Khazars or Slavs” (857). In this brief sentence are a number of fallacies, special pleading, misnomers, false assumptions, sleights of hand, straw arguments and equivocations. This blog  posting can only touch on the controversy, but to begin with, as we have seen, Ashkenazi Jews (n=34, all from New York) are lumped together with Sephardim and Syrian Jews as having Middle Eastern core pedigrees, even though they have the highest amount of local population admixture. Are Khazars the same as Slavs? Not ethnographically. They are sometimes treated as Middle Easterners and sometimes as Europeans or other interlopers in this article, but it doesn’t seem to matter really, because there are no Khazars in the study sample. The authors are thus stalking a phantom, which they duly track down and slay.

Ghost in the Machine

Using haplogroup studies, the authors raise the possibility of 12.5% non-Middle Eastern admixture per generation in Ashkenazi Jews (based on Hammer et al.). They also draw attention to the 7.5% frequency of haplogroup R1a1 among Ashkenazi Jews, a non-Middle Eastern, rather Eastern European male lineage. But R1a1 is not diagnostic of Khazars; try maybe G. R1a1 descendants are typically fair haired and light-eyed; Khazars had a Middle Eastern, Turkic appearance, with dark features.

In a sense, geneticists always seem to find support for what they set out to prove in the first place. It is small wonder that “Abraham’s Fathers” comes at the end of and completes a decades-long push by Big Science to legitimize Jewish claims to Middle Eastern roots. It is a splendid survey, the last in a long series, but it is not the final word on the subject. There are flaws both in the sampling and historical thinking.

The Thirteenth Tribe (1976) by Arthur Koestler, a Hungarian Ashkenazi Jewish author, advanced the thesis that the modern Jewish population in Central and Eastern Europe is not descended from the historical Israelites of antiquity, but from Khazars. This Turkic people of the Caucasus region converted to Judaism in the 8th century and moved into Russia, Hungary, Ukraine, Poland, Belarus, Lithuania and Germany during the 12th and 13th century when the Khazar Empire was collapsing. Koestler's work was founded on that of the French scholar Ernest Renan and set off a firestorm of controversy among Zionists. 




Please tell us what you think

Name, website, and email are optional; if we publish your comment, your name will be shown, and may be linked to your website if provided, but the email you enter will not be published.

Captcha Image

Recent Posts


powwows b'nei anousim Plato Ron Janke Indian Territory Mohawk Freemont Indians Tennessee Smithsonian Magazine Cornwall Cleopatra Ripan Malhi Colima Cohen Modal Haplotype Washington D.C. Barack Obama history of science Bryan Sykes GlobalFiler religion Mark Thomas Panther's Lodge archeology CODIS markers metis Chauvet cave paintings mummies Turkic DNA Chris Tyler-Smith rock art ancient DNA Jews and Muslims in British Colonial America hominids Joseph Andrew Park Wilson Discovery Channel Basques M. J. Harper Gypsies Constantine Rafinesque Celts cannibalism bar mitzvah Melungeon Union Italy Colin Pitchfork King Arthur Neanderthals Taino Indians Neolithic Revolution Science Daily, Genome Biol. Evol., Eran Elhaik, Khazarian Hypothesis, Rhineland Hypothesis Genome Sciences Building Algonquian Indians Harold Sterling Gladwin Abenaki Indians FDA NPR Tintagel Current Anthropology Eric Wayner Michoacan haplogroup C Tucson Oxford Nanopore National Museum of Natural History Salt River occipital bun Cismar Lithuania DNA magazine MHC Tom Martin Scroft genetics Zizmer genealogy Monica Sanowar Columbia University Europe Riane Eisler Havasupai Indians Nadia Abu El-Haj Harry Ostrer Germany Paleolithic Age Ostenaco Pueblo Grande Museum Applied Epistemology Early Jews of England and Wales Akhenaten Middle Eastern DNA X chromosome Maui Oxford Journal of Evolution The Nation magazine Irish Central pheromones Maronites Rafael Falk Rare Genes Wales Jewish genetics Arabia linguistics Sea Peoples Penny Ferguson Anacostia Indians Wendy Roth admixture Texas A&M University far from the tree Sarmatians Jalisco Anasazi Bryony Jones Helladic art aliyah Austro-Hungary haplogroup W Stephen A. Leon Majorca Antonio Torroni Pomponia Graecina New York Academy of Sciences Stony Creek Baptist Church Jan Ravenspirit Franz Panther's Lodge Publishers New York Times Altai Turks Y chromosomal haplogroups Stacy Schiff Stephen Oppenheimer Kitty Prince of the Bear River Athabaskans Jack Goins Ashkenazi Jews Chuetas Virginia genealogy population genetics Population genetics Elizabeth C. Hirschman Nancy Gentry Phyllis Starnes familial Mediterranean fever haplogroup Z Micmac Indians Caucasian Satoshi Horai Michael Grant FOX News Ethel Cox French DNA Timothy Bestor New Mexico autosomal DNA Bulgaria Richard Buckley genomics labs origins of art Ancient Giantns Who Ruled America Pima Indians human migrations Choctaw Indians American history First Peoples Myra Nichols Greeks Bode Technology Sizemore Indians Cherokee Freedmen Horatio Cushman Mucogee Creeks Y chromosome DNA Elizabeth DeLand Phillipe Charlier ged.com Philippa Langley Marija Gimbutas John Ruskamp Life Technologies Wendell Paulson Douglas Owsley Arizona State University Family Tree DNA horizontal inheritance population isolates Irish history personal genomics gedmatch George Starr-Bresette Sam Kean Pueblo Indians Ziesmer, Zizmor anthropology London El Castillo cave paintings Douglas Preston Sasquatch health and medicine Holocaust Miguel Gonzalez Arizona Juanita Sims Waynesboro Pennsylvania Thuya HapMap race George van der Merwede Jon Entine immunology Asiatic Fathers of America Elvis Presley DNA Puerto Rico Phoenix Russell Belk Grim Sleeper Iran Tutankamun Clovis Kate Wong EURO DNA Fingerprint Test Beringia Abraham Lincoln Alia Garcia-Ureste Society for Crypto-Judaic Studies Richmond California human leukocyte antigens African DNA Native American Graves Protection and Repatriation Act Bureau of Indian Affairs Early Jews and Muslims of England and Wales (book) Rich Crankshaw surnames Bradshaw Foundation Michael Schwartz Etruscans Patrick Pynes microsatellites Kurgan Culture peopling of the Americas Teresa Panther-Yates Chromosomal Labs Bode Technology Irish DNA North Carolina Alabama Nova Scotia Comanche Indians PNAS China Erika Chek Hayden Sizemore surname climate change Ireland Smithsonian Institution Melba Ketchum Odessa Shields Cox haplogroup L Jesse Montes Arabic Romania art history James Stritzel Marie Cheng seafaring Navajo Anglo-Saxons mutation rate Jewish GenWeb Ukraine Indo-Europeans Sinaloa AP Luca Pagani Bentley surname research Secret History of the Cherokee Indians BATWING Eske Willerslev Robinson Crusoe Amy Harmon Jim Bentley Nikola Tesla Middle Ages epigenetics Cooper surname Mark Stoneking haplogroup U American Journal of Human Genetics Donald N. Yates Richard Dewhurst Echota Cherokee Tribe of Alabama research Terry Gross haplogroup G Leicester Cajuns Lebanon statistics Tifaneg Tucson crosses Promega Zionism Alec Jeffreys William Byrd Finnish people genetic determinism New York Review of Books Silverbell Artifacts Cherokee DNA alleles Hispanic ancestry Jews FBI DNA testing companies Kari Carpenter Normans Johnny Depp N. Brent Kennedy haplogroup N Theodore Steinberg Melanesians haplogroup B haplogroup E Keros DNA security Stone Age Gunnar Thompson cancer Gravettian culture Charles Darwin Bering Land Bridge news IntegenX Joel E. Harris Sonora Lab Corp University of Leicester Jewish contribution to world literature Roberta Estes private allele 23andme Nature Genetics oncology Black Dutch Sir Joshua Reynolds DNA Fingerprint Test Hopi Indians andrew solomon Louis XVI Scientific American Gregory Mendel Cismaru single nucleotide polymorphism National Geographic Daily News Genex Diagnostics B'nai Abraham Anne C. Stone Native American DNA Telltown Cree Indians methylation Old World Roots of the Cherokee Dragging Canoe Janet Lewis Crain Daniel Defoe Patrick Henry human leukocyte testing genetic memory Hohokam Denisovans clinical chemistry Nature Communications myths Virginia DeMarce Maya Yates surname Bill Tiffee Walter Plecker Mexico education Les Miserables Carl Zimmer Douglas C. Wallace breast cancer Kennewick Man Hawaii Acadians haplogroup R DNA Diagnostics Center Old Souls in a New World corn forensics prehistory Britain Isabel Allende Phoenicians Illumina When Scotland Was Jewish Hohokam Indians Asian DNA Olmec Moundbuilders university of North Carolina at Chapel Hill Cherokee Nation of Oklahoma District of Columbia DNA Forums Melungeon Movement DNA Fingerprint Test palatal tori Kari Schroeder Wikipedia ethnic markers Navajo Indians Anne Marie Fine Melungeon Heritage Association French Canadians ISOGG Wellcome Trust Sanger Institute Central Band of Cherokees Rush Limbaugh consanguinity rapid DNA testing Scotland evolution Hertfordshire hoaxes King Arthur, Tintagel, The Earliest Jews and Muslims of England and Wales Roma People ethnicity Solutreans INORA The Calalus Texts Black Irish DNA databases Mildred Gentry National Health Laboratories Peter Parham BBCNews Egyptians Colin Renfrew clan symbols medicine Khazars Science magazine Chris Stringer mental foramen phenotype Rebecca L. Cann Great Goddess ENFSI Cave art Zuni Indians Henriette Mertz Hadassah Magazine Richard III Cancer Genome Atlas El Paso European DNA bloviators Victor Hugo Cherokee DNA Project haplogroup J haplogroup T Mother Qualla Henry IV John Wilwol Shlomo Sand Stan Steiner family history Ananya Mandal North African DNA Peter Martyr Barnard College Henry VII Nayarit Thruston Tablet Muslims in American history David Reich Epigraphic Society haplogroup X Bigfoot Sorbs Brian Wilkes John Butler Asiatic Echoes Austronesian, Filipinos, Australoid Ancestry.com Nephilim, Fritz Zimmerman Richard Lewontin Gila River Patagonia Khoisan Valparaiso University polydactylism Elzina Grimwood Israel, Shlomo Sand India James Shoemaker Jewish novelists Discover magazine Charles Perou Melungeons haplogroup M Albert Einstein College of Medicine Central Band of Cherokee Kentucky Gustavo Ramirez Calderon Russia prehistoric art Daily News and Analysis England Slovakia David Cornish crypto-Jews Dienekes Anthropology Blog Joseph Jacobs Monya Baker Ari Plost giants Genie Milgrom Svante Paabo haplogroup D haplogroup H mitochondrial DNA Mary Kugler Belgium Israel Native American DNA Test Rutgers University megapopulations Mary Settegast Holocaust Database Fritz Zimmerman pipe carving ethics Sinti Magdalenian culture Charlotte Harris Reese