If you want to discover your genetic history and where you came from... you’ve found the right place!

888-806-2588

review of scientific and news articles on dna testing and popular genetics

Abraham's Children: A Review

Thursday, August 26, 2010

Implications for Jewish History and Genealogy

Article:  Gil Atzmon et al., “Abraham’s Children in the Genome Era:  Major Jewish Diaspora Populations Comprise Distinct Genetic Clusters with Shared Middle Eastern Ancestry,” The American Journal of Human Genetics 86 (June 11, 2010) 850-859.

This blog posting attempts to summarize this important article and translate its technical results into layman’s language for the sake of our customers. From the genetic evidence, we hope to glean some useful information about Jewish history and genealogy, especially for those who find they have “some” Jewish ancestry in their family tree but who are non-Jewish in the way they identify.

The eleven authors represent a stellar team of international researchers specializing in population genetics. The institutions involved are leading centers of genetics and biomedicine, starting with the Albert Einstein College of Medicine in New York and including Tel-Aviv University in Israel. Appearance in the American Journal of Human Genetics, a publication of the American Society of Human Genetics, assures prestige and finality of the highest order.

The study uses a new sample of 237 carefully qualified Jewish subjects, which it compares with data from the Human Genome Diversity Project started at Stanford in the 1990s, as well as the Population Reference Sample (PopRes) project, containing hundreds of thousands of SNPs (single nucleotide polymorphisms, used to differentiate genes that show heredity lines and disease linkage in populations).

The scale of the project is colossal, and it must have taken years to complete. Financial support came from private and public sources, including the U.S.-Israel Binational Science Foundation and NIH. It supersedes (while it confirms or clarifies) the two types of previous approaches to the problem: 1) genetics studies on blood groups from the 1970s, and 2) recent studies of Y chromosomal and mitochondrial haplotypes. The latter “uniparental” studies could only offer a limited view of the subject. This study uses autosomal DNA to its full advantage. The scientists had supercomputers and the latest tools in biostatistics at their disposal.

Material and Methods

The two cornerstones of any statistical study are reliability and validity. Experts would be challenged to find anything wrong with the reliability of “Abraham’s Children.” State-of-the-science genotyping, phylogeny, bootstrapping and GERMLINE algorithms are employed. But validity issues may be mentioned as likely to call some of the findings into slight question in some areas. Subjects were recruited in New York (Iranian, Iraqi, Syrian and Ashkenazi Jews), Seattle (Turkish Sephardic Jews), Greece (Greek Sephardic Jews) and Rome (Italian Jews). The main divisions into Italian, Ashkenazi, Syrian, Middle Eastern (termed Mizrahi, or Eastern, Jews here) can be seen in some instances to be question-begging, and there are equivocations in labels that might, conceivably, create “desired results.” Moreover, subjects “were included only if all four grandparents came from the same Jewish community.” Such a rule might have influenced one of the findings, namely, that “Jewish Communities Show High Levels of IBD,” or Informative By Descent shared segments of DNA (p. 855f.).

Notably, the conclusion that Ashkenazi Jews are highly inbred, with most being as close as 3rd or 4th cousins to each other, could be an effect of the sample selection from New York Ashkenazi Jews, who often emigrated together and belonged to the same synagogue for several generations. A larger, more randomized selection would have been better. The total number of Ashkenazi Jews used was only 34 persons.

Jews now living in Rome are not the same as Roman Jews. Traditional schemes of Jewry speak of the Romaniot Jews, but these were traditionally at home in the Byzantine Empire. Are Syrian Jews mostly Middle Eastern or are they another amalgam of émigrés and remnants? Where are Central Asian Jews like the large Uzbekistani population my local barber represents? The absence of Caucasian and Central Asian Jews may have affected the study’s rather resounding, over-confidant statement that it “refutes” the contention that Ashkenazi Jews have little Middle Eastern heritage and rather more of a contribution to their genetics from Khazars and Slavs. The study, like many, seems at pains to prove Middle Eastern connections of Ashkenazi Jews, who are the leading force in present-day Israel.

There are no German, Dutch, Spanish, Portuguese or English Jews in the study. “Ashkenazi” seems to represent Jews living in New York with rather uniform ancestry in Poland, Hungary, Ukraine, Lithuania and Russia. All Jews in the study seem to be of the “go to temple” (at least on the High Holy Days) sort, although no mention is made of religious orientation. Subjects were chosen because of their ostensibly “pure” Jewish roots.

Ashkenazi Jews at Yom Kippur in 19th century Central Europe from a painting by Gottlieb.

Seven Jewish population clusters are defined: 

  1. Irani Jews
  2. Iraqi Jews
  3. Syrian Jews
  4. Ashkenazi Jews
  5. Italian Jews
  6. Greek Jews
  7. Turkish Jews

These were sorted out into three major groups of the Jewish Diaspora:

  • Eastern European Ashkenazim
  • Italian, Greek and Turkish Sephardim
  • Iranian, Iraqi and Syrian Middle Easterners

How Different are Jews from Each Other? From Non-Jewish Populations?

Table 1 on page 853 shows Fst values, which indicate the degree of projected inbreeding within a cluster and allow one to make comparisons between clusters. If we look at the table of genetic diversity among Jews, we can pick out some of the following points of interest:

  • Ashkenazi Jews are very, very different genetically from Italian (Sephardic) Jews: genetic distance between the two populations is over 3.1, whereas that between Ashkenazi Jews and non-Jewish European populations such as Russian or French hardly ever goes above 1.0.

  • Syrian and Iraqi Jews are also very different from each other; Syrian Jews group together with European (Ashkenazi and Sephardic) Jews, a major finding of the study.

  • All Jewish populations, including Ashkenazim, resemble genetically the Druze, a Middle Eastern population that is still in its original place in Lebanon and Israel. Syrian and Turkish Jews (Sephardim) most resemble Druzes.

The study identifies two major groups of Jews, characterizing them as Middle Eastern Jews and European/Syrian Jews. Of the Middle Eastern Jews, the Irani and Iraqi were scarcely distinguishable. The Europeans have varying degrees of admixture with non-Jewish populations into which they have been dispersed. European Jews are 20-40% (or on another page, 30-60%) European, the study concludes, while Sephardic Jews have 8-11% North African (Berber) DNA. Italian, Syrian, Iranian and Iraqi Jews are the most inbred.

All these statistics “highlight the commonality of Jewish origin” and expose the Middle Eastern origins and genetic unity of Jewish people, even in dispersal from their homeland in ancient Israel.

The flipside of inbreeding is outbreeding or exogamy. If European Jews are highly admixed, by the same token, many Europeans must have some degree of Jewish admixture. Gene flow did not go just one way. What are the most outbred Jewish clusters according to the study? It is the Sephardic Jews from Italy, Greece and Turkey, with low rates of shared IBD and greater diversity than the Ashkenazim.

Lost Tribes Still Lost

 The brief Discussion section at the end of the article attempts to put the statistical findings together with an outline of Jewish history and resolve some of the mysteries of Jewish genetic makeup, chiefly the Khazar question. “Each of the Jewish populations formed its own cluster as part of the larger Jewish cluster,” the authors conclude. “Each group demonstrated Middle Eastern ancestry and variable admixture with European populations.”

Next, the authors attack the difficulty of determining when the major split between Eastern and Western Jewish groups occurred (with Syrians falling out with the Sephardim and Ashkenazim in the West, although intermediate in genetic distance with Middle Eastern Jews like the Iraqi and Irani). Based on IBD or calculations of shared genes on the front end or bottlenecks and back end or genetic drift, “a split between Middle Eastern Iraqi and Iranian Jews and European/Syrian Jews…is 100-150 generations [or] 2500 years ago.” They correlate this population divide with the Babylonian and Persian periods of Jewish history. These disturbances began in the 900s-800s BCE when the Kingdom of David fell apart into the Kingdom of Jerusalem and the Northern Kingdom (Samaria , Israel, Ephraim) and were finalized in the 6th century BCE when King Cyrus of Persia granted permission to the exiles to be repatriated from Babylon to Jerusalem.

In the shuffle, the so-called Lost Tribes representing the Northern Kingdom had been dispersed “beyond the river” into Central Asia, leaving the Judeans in the ascendancy in Israel. Although the authors do not explicity state it, the fact that Syrian Jews are several quantums’ length closer in affinity with European Jews than Middle Eastern Jews seems to reflect the historic Return to Zion and inauguration of the Second Temple in Jerusalem in 516 BCE and explain why European Jews, especially Sephardim, emphasize the House of David and Tribes of Levi in their traditional ancestral accounts. So far, the autosomal clock of change seems to beat with the march of history.

 

Khazar kingdom in the Middle Ages.

The article is clear about another thing, “the idea of non-Semitic Mediterranean ancestry in the formation of the European/Syrian Jewish groups,” attributing this to the mass conversions and proselytism during Greco-Roman times. It mentions that there were six million Jews in the Roman Empire, when Judaism accounted for 10% of the population. But here is where the authors’ sense of history begins to get fuzzy. They do not speak of medieval conversions or mention, for instance, the Jews of Visigothic and Berber Spain and Septimanian France and gloss over the huge Khazar conversion and expansion event, 600-1000 CE. Again, medieval history does not seem to be geneticists’ strength.

“Abraham’s Children” claims that the genetic composition of European/Syrian Jewish groups “is incompatible with theories that Ashkenazi Jews are for the most part the direct lineal descendants of converted Khazars or Slavs” (857). In this brief sentence are a number of fallacies, special pleading, misnomers, false assumptions, sleights of hand, straw arguments and equivocations. This blog  posting can only touch on the controversy, but to begin with, as we have seen, Ashkenazi Jews (n=34, all from New York) are lumped together with Sephardim and Syrian Jews as having Middle Eastern core pedigrees, even though they have the highest amount of local population admixture. Are Khazars the same as Slavs? Not ethnographically. They are sometimes treated as Middle Easterners and sometimes as Europeans or other interlopers in this article, but it doesn’t seem to matter really, because there are no Khazars in the study sample. The authors are thus stalking a phantom, which they duly track down and slay.

Ghost in the Machine

Using haplogroup studies, the authors raise the possibility of 12.5% non-Middle Eastern admixture per generation in Ashkenazi Jews (based on Hammer et al.). They also draw attention to the 7.5% frequency of haplogroup R1a1 among Ashkenazi Jews, a non-Middle Eastern, rather Eastern European male lineage. But R1a1 is not diagnostic of Khazars; try maybe G. R1a1 descendants are typically fair haired and light-eyed; Khazars had a Middle Eastern, Turkic appearance, with dark features.

In a sense, geneticists always seem to find support for what they set out to prove in the first place. It is small wonder that “Abraham’s Fathers” comes at the end of and completes a decades-long push by Big Science to legitimize Jewish claims to Middle Eastern roots. It is a splendid survey, the last in a long series, but it is not the final word on the subject. There are flaws both in the sampling and historical thinking.

The Thirteenth Tribe (1976) by Arthur Koestler, a Hungarian Ashkenazi Jewish author, advanced the thesis that the modern Jewish population in Central and Eastern Europe is not descended from the historical Israelites of antiquity, but from Khazars. This Turkic people of the Caucasus region converted to Judaism in the 8th century and moved into Russia, Hungary, Ukraine, Poland, Belarus, Lithuania and Germany during the 12th and 13th century when the Khazar Empire was collapsing. Koestler's work was founded on that of the French scholar Ernest Renan and set off a firestorm of controversy among Zionists. 

 

 

Comments

Please tell us what you think

Name, website, and email are optional; if we publish your comment, your name will be shown, and may be linked to your website if provided, but the email you enter will not be published.





Captcha Image


Recent Posts


Tags

Virginia DeMarce Virginia genealogy corn history of science Telltown Richard Dewhurst population genetics Gravettian culture Patagonia ancient DNA university of North Carolina at Chapel Hill Harry Ostrer Jewish novelists rock art IntegenX human leukocyte testing bar mitzvah Scotland Sinti Ananya Mandal First Peoples Albert Einstein College of Medicine Lebanon Cooper surname Theodore Steinberg anthropology American Journal of Human Genetics Janet Lewis Crain Harold Sterling Gladwin Middle Ages genetic determinism haplogroup R Melungeons Jewish genetics Population genetics art history alleles Sasquatch Cismar Britain Nikola Tesla Sinaloa B'nai Abraham Ziesmer, Zizmor Basques Kate Wong England Early Jews of England and Wales seafaring Smithsonian Institution Bryan Sykes Melungeon Movement Charles Perou Roma People Pima Indians Horatio Cushman Khoisan Romania Anne Marie Fine education Gypsies medicine Science magazine Phoenicians Svante Paabo Philippa Langley Chuetas Germany Bulgaria Eric Wayner immunology Michael Schwartz Europe prehistoric art Mary Settegast National Health Laboratories Mark Thomas forensics Tom Martin Scroft Bureau of Indian Affairs Charlotte Harris Reese Cherokee DNA Altai Turks Jewish GenWeb Bode Technology University of Leicester Celts single nucleotide polymorphism Tennessee haplogroup B Jim Bentley Pueblo Indians news Ripan Malhi statistics Moundbuilders Bradshaw Foundation Tifaneg Maronites North African DNA Black Dutch Daniel Defoe Arabia Arabic Barnard College Nature Communications Maya Austro-Hungary Epigraphic Society Oxford Journal of Evolution John Wilwol Russia Discovery Channel origins of art familial Mediterranean fever polydactylism Elzina Grimwood Anasazi Henry IV Hertfordshire Johnny Depp Melungeon Heritage Association X chromosome Caucasian Irish DNA Monya Baker Pomponia Graecina BATWING Society for Crypto-Judaic Studies Havasupai Indians Wales Neolithic Revolution genetics pheromones Choctaw Indians Y chromosome DNA Alabama Bentley surname research Finnish people Sea Peoples Kari Carpenter Olmec Nephilim, Fritz Zimmerman Jone Entine Roberta Estes Tucson Wikipedia Denisovans DNA testing companies Great Goddess research Panther's Lodge Teresa Panther-Yates Bryony Jones Mary Kugler Solutreans Khazars New York Academy of Sciences Leicester Douglas Preston Mexico Belgium MHC Sarmatians Kennewick Man Cleopatra Scientific American King Arthur, Tintagel, The Earliest Jews and Muslims of England and Wales American history linguistics DNA security Peter Martyr Valparaiso University Neanderthals haplogroup M haplogroup X 23andme Cancer Genome Atlas M. J. Harper James Shoemaker Richard Buckley megapopulations Russell Belk French Canadians Sonora Henry VII Phyllis Starnes cannibalism peopling of the Americas Panther's Lodge Publishers Rare Genes occipital bun Akhenaten Abraham Lincoln Louis XVI The Nation magazine haplogroup Z DNA Forums Algonquian Indians Tutankamun Jack Goins ethics Nadia Abu El-Haj Muslims in American history Carl Zimmer National Museum of Natural History Egyptians clinical chemistry Bill Tiffee Gregory Mendel Holocaust Database Jews King Arthur Old Souls in a New World Current Anthropology Les Miserables Acadians Sizemore surname When Scotland Was Jewish Jon Entine Melba Ketchum Cismaru phenotype GlobalFiler Miguel Gonzalez NPR Michael Grant Chauvet cave paintings William Byrd Victor Hugo Zizmer Chris Stringer Kari Schroeder palatal tori hominids Jalisco microsatellites Secret History of the Cherokee Indians Daily News and Analysis National Geographic Daily News Y chromosomal haplogroups George van der Merwede Jewish contribution to world literature Charles Darwin giants North Carolina Zuni Indians George Starr-Bresette French DNA Melungeon Union Marija Gimbutas haplogroup E PNAS Promega Sorbs Barack Obama surnames Slovakia Gunnar Thompson Texas A&M University Israel, Shlomo Sand mental foramen aliyah Lithuania N. Brent Kennedy DNA Fingerprint Test Rich Crankshaw haplogroup L Italy Anglo-Saxons Nayarit New Mexico Greeks far from the tree horizontal inheritance haplogroup N CODIS markers Ukraine DNA magazine Bigfoot Austronesian, Filipinos, Australoid David Cornish Wellcome Trust Sanger Institute Stone Age Yates surname Etruscans Cajuns ISOGG genealogy Richard Lewontin Gila River genetic memory Ari Plost John Butler New York Review of Books Hohokam Colin Pitchfork Asiatic Fathers of America hoaxes Erika Chek Hayden Harold Goodwin Indo-Europeans haplogroup J autosomal DNA Elvis Presley DNA AP Black Irish mutation rate Anacostia Indians Terry Gross Luca Pagani BBCNews Sam Kean Beringia HapMap Sizemore Indians race INORA DNA databases Oxford Nanopore Joseph Jacobs FBI cancer Robinson Crusoe Ashkenazi Jews District of Columbia Magdalenian culture ethnicity Arizona State University powwows Fritz Zimmerman El Castillo cave paintings Middle Eastern DNA Penny Ferguson Rafael Falk Wendell Paulson New York Times EURO DNA Fingerprint Test Nova Scotia FDA Bering Land Bridge Navajo Ancient Giantns Who Ruled America Waynesboro Pennsylvania Constantine Rafinesque Iran Chris Tyler-Smith Thuya Stony Creek Baptist Church Alec Jeffreys personal genomics London Patrick Henry population isolates breast cancer oncology Rush Limbaugh Life Technologies Marie Cheng admixture Douglas Owsley Shlomo Sand Rutgers University Keros Applied Epistemology Salt River family history Isabel Allende Washington D.C. Turkic DNA Riane Eisler Kentucky Ireland consanguinity Grim Sleeper Monica Sanowar Smithsonian Magazine epigenetics Timothy Bestor Wendy Roth European DNA prehistory mitochondrial DNA Phillipe Charlier Native American DNA Cave art Jews and Muslims in British Colonial America Science Daily, Genome Biol. Evol., Eran Elhaik, Khazarian Hypothesis, Rhineland Hypothesis Micmac Indians Paleolithic Age Richard III human leukocyte antigens Peter Parham religion Lab Corp Genome Sciences Building mummies Majorca Pueblo Grande Museum Tintagel crypto-Jews Nature Genetics haplogroup T Israel Freemont Indians health and medicine andrew solomon Irish Central Normans ethnic markers Zionism Kurgan Culture FOX News Abenaki Indians Walter Plecker Early Jews and Muslims of England and Wales (book) China Donald N. Yates Native American Graves Protection and Repatriation Act evolution Henriette Mertz Amy Harmon Stacy Schiff Plato myths Phoenix Stan Steiner Chromosomal Labs Bode Technology India Clovis Cohen Modal Haplotype Irish history Hohokam Indians Colima Holocaust bloviators Melanesians archeology climate change Arizona methylation haplogroup U genomics labs ENFSI Hopi Indians Ron Janke African DNA DNA Fingerprint Test Asian DNA Columbia University Native American DNA Test private allele human migrations clan symbols Cornwall rapid DNA testing Stephen Oppenheimer Colin Renfrew Helladic art haplogroup H Comanche Indians Discover magazine Elizabeth C. Hirschman Michoacan Dienekes Anthropology Blog

Archive