Two reports in the European Journal of Human Genetics underline how specific autosomal DNA can be in revealing the geographical structure among populations. One uses genome-wide data from the Illumina Human Hap300 project to predict the village of origin of a person's four grandparents given European origins. The other used genotyping from 3,367 individuals from seven different European, mostly British Isles populations to lay bare the detailed population structure and linkage disequilibrium patterns of Ireland, England, Scotland and Wales.
Both studies have Colm O'Duschlaine of Trinity College, Dublin as their lead author and highlight how genotyping with autosomal DNA dominates genetics today (and DNA testing), eclipsing in many respects the older style of tests known as sex-linked haplotyping or lineage analysis, which focused on the male Y chromosome and female mitochondrial lines only.
Colm O'Duschlaine et al., "Genes Predict Village of Origin in Rural Europe," Eur. J of Hum. Genet. (2010) 18, 1269-1270. Abstract.
Colm O'Duschlaine et al., "Population Structure and Genome-Wide Patterns of Variation in Ireland and Britain," Eur. J of Hum. Genet. (2010) 18, 1248-1254. Abstract.
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Two New Autosomal DNA Population Studies: England, Ireland and Rural Europe
Thursday, April 14, 2011
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