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In a review of Chris Stringer's book The Origin of Our Species (Lane, 2011), Jean-Jacques Hublin sides with one of the first promoters of the 30-year old Recent African Origin hypothesis and supports the notion that modern humans out of Africa entirely replaced Neanderthals because they were, well, fitter and superior.

See "Palaeoanthropology:  African Origins" in Nature 476, 395 (August 25, 2011).

But could the true scenario have been that "we" were already hybridized with Neanderthals, and that's why "we" won out? Recent work has brought evidence that Neanderthals gave "us" our immunities to a wide range of disease and thus allowed "us" to survive. The question doesn't have to be an either/or dilemma.

Above:  Krapina Neanderthal Museum. N. Solic.

According to a professor of immunology and microbiology at Stanford University, humans were able to survive, spread and expand their populations once they left Africa because of immunities to disease they acquired from Neanderthals and Denisovans, who had lived in Europe and Asia already for hundreds of thousands of years.

A review of the new research appears in the online science magazine Discover under the date of June 20, 2011. The professor's name is Peter Parham.

Crux of the matter, according to Royal Society report

• Parham began by taking a close look at a family of genes called  human leukocyte antigens (HLAs), which play a central role in our body’s immune responses. We are able to react to a wide array of diseases because our HLA genes are highly variable, each containing dozens of  alleles (forms of genes).
• Our ancestors in Africa, however, would have had a small number of HLA alleles because they likely traveled in small bands and had little contact with other groups. Moreover, their HLAs would have only protected them against African diseases.
• When Parham compared the HLAs of modern humans with those of Neanderthals and Denisovans, he noticed some overlaps. In particular, he found that HLA-C*0702, an allele common in Europeans and Asians but nonexistent in Africans, was also present in the Neanderthal genome. Similarly, HLA-A*11, which is found in modern Asians but not in Africans, popped up in Denisovan DNA.
• Overall, about 50 percent of HLA Class I alleles in Europeans seemed to come from Neanderthals, 70 to 80 percent in East Asians from Denisovans, and 90 to 95 percent in Papuans from Denisovans, Parham said at a recent Royal Society meeting.

The latest revelation about the true nature of Neanderthals shows how fast current scientific and popular thinking is moving on the subject. Two years ago it was still debated whether "humans" could interbreed with Neanderthals, or whether Neanderthals were even a human species. Denisovans were only discovered in the last year.

DNA Consultants introduced its Neanderthal Index, a measure of affinity with archaic populations of Europe and the Middle East, one year ago this month.

Dr. Donald Yates says he is planning a visit to Vindija cave near Varazdin in Croatia this month to see firsthand the world's most important site for the discovery of Neanderthal bones and lifeways, dating to about 30,000 years ago.

Human history changed drastically with the 1974 Neanderthal discoveries at Vindija Cave. Photo Tomislav Kranjcic.

As Revealed by Autosomal Markers

No scientific work, to our knowledge, has ever hazarded a guess on what the mutation rate for autosomal CODIS-type markers might be. Is it like mitochondrial DNA, which has a molecular clock measured in the thousands or tens of thousands of years, or is it like STRs on the Y chromosome, with its much shorter timeframe? The question is important if you are trying to extrapolate the history of the human race from today's autosomal population statistics.

From what we can see, putting on diachronistic lenses, the mutation rates for the DYS values on what are commonly called CODIS markers or the DNA profile for individuals are very small. The values appear to have been set from the beginning of mankind and to have mutated little in the past 100,000 years.

If this is true -- and it cannot be a very big "if" or we would have more diversity between populations than what is known -- the oldest markers are Sub-Saharan African and the newest European. Statistical divides bear out this reading of the human genetic record, as shown now in our updated map included with the DNA Fingerprint Plus.

We will try to make some notes on the individual markers in future posts.

In 2009-2010, an analysis of 11 royal mummies from around 1300 BCE was carried out by an Egyptian team under the country's chief archeologist Zahi Hawass. A television special was produced, titled "Unwrapping King Tut." Hawass and his colleagues published "Ancestry and Pathology in King Tutankhamun's Family," in JAMA, vol. 303, no. 7. (Feb. 17, 2010).

In a fun review article earlier this year, British journal New Scientist's Jo Marchant summarized much of the resulting controversy. See her "Royal rumpus over King Tutankhamun's Ancestry."

We'd be interested in seeing Tut and the other putative family members' DNA fingerprint scores at the bottom of the mystery but are not aware that Hawass and his team actually published the bona fides of their investigations. From a cursory look, it is evident to us that Amenhotep and his descendants, including Akhenaten, Tutankhamun and his unidentified mother (Nefertiti? Tiye?), all bore our marker Asian III.

Unsurprisingly, none of the royal mummies seems to have carried a Jewish marker. It is unclear from the limited data revealed to the world by Hawass whether any had Sub-Saharan African markers.

The new Tut tiff swirls around the question of the pharaohs' African and Western European ethnicity. Without being able to shed light on that, our 18 Marker Ethnic predictor at least suggests they had Asian. Of course, this is not to say they were Asian primarily, since all peoples, ancient and modern, are mixed and may exhibit a variety of ethnic markers in their autosomal DNA.

Above:  British Museum's wood and ivory painted chest lid from the royal tomb shows Tutankhamen leaning on a staff with his sister-wife Ankhesenamun presenting him with a lotus flower. Inbreeding and genetic disease spelled the end of the dynasty.

The Southern Route “Out of Africa”: Evidence for an Early Expansion of Modern Humans into Arabia

Science 28 January 2011: Vol. 331 no. 6016 pp. 453-456 DOI: 10.1126/science.1199113

By Simon J. Armitage, Sabah A. Jasim, Anthony E. Marks, Adrian G. Parker, Vitaly I. Usik, and Hans-Peter Uerpmann

Abstract

The timing of the dispersal of anatomically modern humans (AMH) out of Africa is a fundamental question in human evolutionary studies. Existing data suggest a rapid coastal exodus via the Indian Ocean rim around 60,000 years ago. We present evidence from Jebel Faya, United Arab Emirates, demonstrating human presence in eastern Arabia during the last interglacial. The tool kit found at Jebel Faya has affinities to the late Middle Stone Age in northeast Africa, indicating that technological innovation was not necessary to facilitate migration into Arabia. Instead, we propose that low eustatic sea level and increased rainfall during the transition between marine isotope stages 6 and 5 allowed humans to populate Arabia. This evidence implies that AMH may have been present in South Asia before the Toba eruption (1).

First paragraph.
The deserts of the Arabian Peninsula have been thought to represent a major obstacle for human dispersal out of Africa. AMH were present in East Africa by about 200 thousand years ago (ka) (2). It is likely that the first migration of AMH out of Africa occurred immediately before or during the last interglacial [marine isotope stage (MIS) 5e] (3). During MIS 6, the Afro-Asiatic arid belt was hyperarid, restricting movements of human populations out of Africa. Finds from Qafzeh and Skhul in the Near East, dated between 119 ± 18 and 81 ± 13 thousand years ago (ka) (4, 5), suggest that AMH first migrated along the “Nile Corridor” and into the Levant. 

Native Hawaiians and Native Americans
Part One

In a previous post, "On the Trail of Spider Woman," we suggested that petroglyphs in Arizona and Utah with female goddess symbolism and birthing ceremonies were connected with the Hohokam ("Sea Peoples") and other Indians who followed in their wake, corresponding to archeology and anthropology's Basketmaker Culture. In this and a series of posts over the next few months, we will show pictures of “emergence” petroglyphs from Hawaii, New Guinea, California, Hopi, Zuni, Pima, Papago, Fremont, Zuni, Mimbres, Palavayu and Eastern Woodlands cultural sites that support our thesis. We believe them to be the footsteps and stepping stones of female haplogroup B and its associated lineages.

Mitochondrial Haplogroup B does not have as its dissemination center Mongolia or Siberia or Central Asia but Southeast Asia, specifically Taiwan and Indonesia, and is characteristic, in contrast with Indian groups emphasizing A, C and D, of the Pueblo Indians and some Southeastern Indians such as the Cherokee and Chickasaw and Choctaw. It entered the Americas in successive waves, some of them seaborne, over many millennia.

The first picture comes from the western coast of the island of Hawaii. It is considered one of the oldest religious shrines in the Hawaiian Islands. It shows a stick figure carved into a rock set in the ground. As we will see, this is a typical "emergence" figure marking the arrival of a people in a new phase of existence. The symbolism is of a female mother figure giving birth, her progeny here depicted by the taillike extension coming from between her legs. There are thousands of variations of this tribal or clan mother iconography scattered over Asia and the Americas (but not apparently found in Europe or Africa).

The Hawaiians considered the western coast of the Big Island their place of emergence. According to their legends, their people came from the sea from the southwest and were noted for their ability to twist plants and fibers into ropes. Their capital was hence called Hilo (twisted, plaited). On account of their subtlety in these arts they adopted the hula (twist) dance as their national dance. Its original purpose was as a fertility ritual to increase population. (Johannes C. Andersen, Myths and Legends of the Polynesians, Tokyo:  Tuttle, 1969.) The main song sung during the enactment of the hula was called The Water of Kane, or Waters of Life.

The Hawaiian Mother symbol illustrated above seems to be connected with a certain clan. As is often the case, the head of the female figure is differentiated to show which clan. This one has horns and could represent a dragonfly. This insect recurs in American Indian petroglyphs where it is associated with the Water Clan and fertility rites. To "read" the Hawaiian petroglyph properly we might say, "Here is the spot where the Head Mother of the Water Clan emerged and gave birth to her people." It is likely (although no legends are preserved regarding its use) that women made offerings here to become fertile, attract husbands and be delivered of healthy children. In similar ceremonial sites, such figures mark an actual birthing stone where women squatted to give birth, attended by midwives and clan mothers.

Native American Parallels

To show the physical resemblance of the Hawaiian design to American Indian symbols we will reproduce  thumbprints below from different traditions. They will be linked together and explicated in subsequent posts in this series.

"Lizard Woman" petroglyphs from Arizona/Utah.

"Lizard figure" at "ceremonial" Burnt Ridge Petroglyph Site, Madison County, Kentucky.


Water Clan symbols from petroglyph handbook, Springerville (Zuni) cultural territory in Arizona. From left:  meander, snake, chevrons in triline, emergence.

The Y-chromosome landscape of the Philippines: extensive heterogeneity and varying genetic affinities of Negrito and non-Negrito groups

Frederick Delfin1,2, Jazelyn M Salvador1, Gayvelline C Calacal1, Henry B Perdigon1, Kristina A Tabbada1, Lilian P Villamor1, Saturnina C Halos1, Ellen Gunnarsdóttir2, Sean Myles1,6, David A Hughes2, Shuhua Xu3, Li Jin3, Oscar Lao4, Manfred Kayser4, Matthew E Hurles5, Mark Stoneking2 and Maria Corazon A De Ungria1

European Journal of Human Genetics (2011) 19, 224–230; doi:10.1038/ejhg.2010.162; published online 29 September 2010

Abstract

The Philippines exhibits a rich diversity of people, languages, and culture, including so-called ‘Negrito’ groups that have for long fascinated anthropologists, yet little is known about their genetic diversity. We report here, a survey of Y-chromosome variation in 390 individuals from 16 Filipino ethnolinguistic groups, including six Negrito groups, from across the archipelago. We find extreme diversity in the Y-chromosome lineages of Filipino groups with heterogeneity seen in both Negrito and non-Negrito groups, which does not support a simple dichotomy of Filipino groups as Negrito vs non-Negrito. Filipino non-recombining region of the human Y chromosome lineages reflect a chronology that extends from after the initial colonization of the Asia-Pacific region, to the time frame of the Austronesian expansion. Filipino groups appear to have diverse genetic affinities with different populations in the Asia-Pacific region. In particular, some Negrito groups are associated with indigenous Australians, with a potential time for the association ranging from the initial colonization of the region to more recent (after colonization) times. Overall, our results indicate extensive heterogeneity contributing to a complex genetic history for Filipino groups, with varying roles for migrations from outside the Philippines, genetic drift, and admixture among neighboring groups.

Genetic history of an archaic hominin group from Denisova Cave in Siberia

By David Reich et al.

Nature 468: 1053-60.

Published online

22 December 2010

Abstract

Using DNA extracted from a finger bone found in Denisova Cave in southern Siberia, we have sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is from a group that shares a common origin with Neanderthals. This population was not involved in the putative gene flow from Neanderthals into Eurasians; however, the data suggest that it contributed 4–6% of its genetic material to the genomes of present-day Melanesians. We designate this hominin population ‘Denisovans’ and suggest that it may have been widespread in Asia during the Late Pleistocene epoch. A tooth found in Denisova Cave carries a mitochondrial genome highly similar to that of the finger bone. This tooth shares no derived morphological features with Neanderthals or modern humans, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans.

Book:  Past Human Migrations in East Asia. Matching Archeology, Linguistics and Genetics, ed. Alicia Sanchez-Mazas et al. Routledge, Taylor & Francis, 2008.

According to the reviewer of this compilation of interdisciplinary studies, Frank Roels, writing in European Journal of Human Genetics 18:262f., the three approaches are incommensurate because of differing timeframes and rates of change. Their models cannot be harmonized with sufficient reliability to write a comprehensive, persuasive history of human migrations and settlements in East Asia.