DNA Consultants Home of the DNA Fingerprint

2011 has gone down as the year of faked scholarship, but what if sound (if undaring) research is the victim of scientists' golden dreams of glory?

The prestigious journal Human Immunology first published the article "The Origin of Palestinians and Their Genetic Relatedness with Other Mediterranean Populations," then yanked it, instructing their subscribers to rip out the offending pages because they showed that Middle Eastern Jews and Palestinians are genetically almost identical. As of today, we still found the article online along with the editor's retraction and protests, but you'd better hurry if you want to read it. The censors who guard the scientific fables about Jewish DNA may discover a way to rewrite World Wide Web history as well as world history.

In the meantime, you can read about the whole lamentable mess in The Guardian in a story by Robin McKie, "Journal Axes Gene Research on Jews and Palestinians."

Gene surfing is a process in population expansion whereby certain variations become prominent and dominant in a short time, appearing to skip the slow, steady, uniform accumulation of variegation and diversification. According to a study of the population structure and genealogies of Saguenay Lac-Saint-Jean in Quebec, this type of drastic change accompanied the immigrant wave front that spread over the area in the 17th century. "Deep Human Genealogies Reveal a Selective Advantage to Be on an Expanding Wave Front" in Science magazine describes the resulting demographics.

Abstract
Since their origin, human populations have colonized the whole planet, but the demographic processes governing range expansions are mostly unknown. We analyzed the genealogy of more than one million individuals resulting from a range expansion in Quebec between 1686 and 1960 and reconstructed the spatial dynamics of the expansion. We find that a majority of the present Saguenay Lac-Saint-Jean population can be traced back to ancestors having lived directly on or close to the wave front. Ancestors located on the front contributed significantly more to the current gene pool than those from the range core, likely due to a 20% larger effective fertility of women on the wave front. This fitness component is heritable on the wave front and not in the core, implying that this life-history trait evolves during range expansions.

So gene surfing in an expanding colonization phase can produce a genetic revolution whose effects will be felt for hundreds or thousands of years downstream in history.

We wonder if the same wave front demographics might explain some of the following population phenomena:

• Large scale triumph of Norman male lineages following the conquest of England in 1066.
• Selective expansion of Middle Eastern genes in Tennessee (including Cherokee families, Jewish male and female lines and Melungeons)
• Relatedness among Jews and "Jewish diseases"
• Diversity-within-uniformity of Polynesians
• Population replacement of Old European (U, N) by Middle Eastern genes (T, J)  in Europe as a result of the Neolithic Agricultural Revolution

Many students of history are puzzled why old populations have the allele frequencies and heterozygosity clines they have. Genetic drift is only part of the answer. Gene surfing and selection in deep history are the rest of it.

It used to be thought that the Sorbs, a medieval East German Slavic population, formed the core of a group of Jews who ended up as the dominant element of Ashkenaz, Eastern Jews in Poland, Lithuania, Ukraine, Silesia and Russia. No longer.

According to an article published in European Journal of Human Genetics (2011) 19, 995-1001, "Genetic Variation in the Sorbs of Eastern Germany in the Context of Broader European Genetic Diversity," by Veeramah et al., the Sorb "population isolate" is not that isolated but was "less than that observed for the Sardinians and French Basque," true isolates. Sorbs are in reality part of the larger population of West Slavs, including Poles and Czechs, and scarcely distinguishable from them.

Histories of Judaism will have to revise their accounts of the genesis of Ashkenazim accordingly. The story of European Jews is more diversified and dynamic than most history or coffee-table type books allow.

Abstract.

For an example of a research article on Ashkenazi roots overemphasizing Sorbs, see Behar et al. who theorizes they were a leading constituent of Levites.



Charlemagne subjugates pagans in Germany.

DNA Consultants' fourth Jewish marker, Tatar/Khazar, has been renamed Jewish IV, bringing it into line with European, Asian and Sub-Saharan African marker groups. All these populations have four markers in acknowledgment of their complexity, age and diversity.

Native American has only two markers.

Jewish IV can be expected to be more sensitive following the addition of Altai Turkic, Caucasus, Southern Russian and Khazak population data to the company's computer program atDNA.

The four Jewish markers may be described as follows:

JEWISH I. This is the most common of the three markers. It can occur without known Jewish ancestry for a variety of reasons including an ancestor’s conversion to Christianity during the centuries of persecutions against Jews in Europe. Its frequency is highest in Poles, Russians, Germans, Hungarians, Romanians and Slavic peoples who intermarried with Ashkenazi Jews. It also appears in Spanish, Portuguese and Moroccan Jews (Sephardim).

JEWISH II. This marker is the strongest. It is found in Jewish families who have intermarried with other Jews down through the centuries. It is characteristic of Ashkenazi Jews.

JEWISH III.  This marker is an indication of Middle Eastern roots. Preserved by Jews, it is also borne by Kurds, Syrians, Arabs, Berbers, Basques, Turks, Greeks, Italians and other populations from the ancient world.

JEWISH IV. A marker indicative of Tatar or Khazar heritage. Khazars were a Central Asian people of Turkic, Hunnish and Iranian elements that arose in the Caucasus region. After converting to Judaism in the early Middle Ages, they moved westward into Russia and the Ukraine under pressure from Islam, eventually becoming a large component of Eastern and Central European Jewry. Many Ashkenazi Jews now find they have some Khazar (or intermingled Tatar) ancestry.

As can be seen, these divisions reflect the three major convert populations of Judaism, Sephardim, Ashkenazim and Khazars (often referred to as "the thirteenth tribe") in addition to the original Middle Eastern Israelites and related people of the Bible (Jewish III), which forms the core genetic element of solidarity.

Khazar rabbis.

This posting will review some of the material we have previously made available about the science behind our three Jewish markers in the autosomal 18 Marker Ethnic Panel. First, it may be worthwhile to recount the chronology of our testing innovations in this area.

2006 - DNA Consultants introduces the DNA Fingerprint Test, one of the first simple autosomal ancestry tests based on population databases

2009 -Donald N. Yates, Ph.D., principal investigator, makes the discoveries in July that lay the foundation for the DNA Fingerprint Plus, rolled out in early September. The enhanced product includes simple autosomal markers for Native American, European, Jewish, Asian and African ancestry, based upon their frequencies of occurrence in these ethnicities.

2010 - Several important studies on Jewish genetics appear; DNA Consultants introduces Jewish DNA Test

2011 - DNA Consultants releases version 2.0 of its autosomal population database atDNA, marking the addition of the population Melungeon (n=40).

One of the first of the Jewish markers to be blogged about was Jewish II, characteristic of Ashkenazi Jews. Theodor Herzl, the nineteenth-century Austro-Hungarian Zionist thinker-organizer who helped inspire the founding of the State of Israel, is an example of a famous Ashkenazi Jew. There was another post titled Jewish Marker II Statistical Notes.

A post on Jewish I soon followed, together with a discussion about its European connections. There has been an ongoing discussion on the Jewish Forum on DNA Communities.

Jewish III has been the slowest to emerge. Its Middle Eastern nature has been explored and expanded upon in several threads on DNA Communities.

In the Fall of 2010, our project administrator tabulated results for more than 450 people who had ordered a Jewish Ancestry Test through our partner Jewish Voice. It was found that 99.97% showed at least one Jewish marker, that is, had some Jewish ancestry.  Some had all three markers while others had a combination of the three in some way.  The informal study indicated 74% of Jewish Ancestry Test takers had Jewish I, 30% had Jewish II and 82% Jewish III.

Then:  Genes of Old Testament Priests (Cohanim)
Now:  Genetic Traces of Religions in Lebanese and Iranians

Then:  Rare Genetic Disorders in Finnish Mitochondrial Haplotypes (U)
Now:  Genome-Wide Association Studies in Saami

The whole business of direct-to-the-consumer DNA tests was founded upon the revelation in 1997 that Jewish men with the last name Cohen ("priest" in Hebrew) or something similar often preserved the genetic signature of Old Testament priests in the Y chromosome type handed down from father to son. Last year at long last, the so-called Cohen Modal Haplotype was completely pinned down and defined to everyone's satisfaction ("Does He or Doesn't He?"). Now similar genetic traces are being sought, and found, for other religions from the Middle East.

In response to customers asking whether being a Jew was a matter of ancestry or culture, genes or religion, I used to say, "Genes don't have religion, genes are older than religions, your DNA doesn't know what religion you are." But the increasingly adept methods of populations genetics are changing that pat response. The key tool is a program that uses advanced statistics to estimate population differentiations, BATWING. Standing for Bayesian Analysis of Trees With Internal Node Generation, this software can calculate the effective population sizes and growth rates from microsatellite data, assuming there was a split into several populations in the past. It is a little over 10 years old. The following article is likely to become a classic in this regard:

Influences of history, geography, and religion on genetic structure: the Maronites in Lebanon

Marc Haber et al.

European Journal of Human Genetics (2011) 19, 334–340; doi:10.1038/ejhg.2010.177; published online 1 December 2010

Abstract

Cultural expansions, including of religions, frequently leave genetic traces of differentiation and in-migration. These expansions may be driven by complex doctrinal differentiation, together with major population migrations and gene flow. The aim of this study was to explore the genetic signature of the establishment of religious communities in a region where some of the most influential religions originated, using the Y chromosome as an informative male-lineage marker. A total of 3139 samples were analyzed, including 647 Lebanese and Iranian samples newly genotyped for 28 binary markers and 19 short tandem repeats on the non-recombinant segment of the Y chromosome. Genetic organization was identified by geography and religion across Lebanon in the context of surrounding populations important in the expansions of the major sects of Lebanon, including Italy, Turkey, the Balkans, Syria, and Iran by employing principal component analysis, multidimensional scaling, and AMOVA. Timing of population differentiations was estimated using BATWING, in comparison with dates of historical religious events to determine if these differentiations could be caused by religious conversion, or rather, whether religious conversion was facilitated within already differentiated populations. Our analysis shows that the great religions in Lebanon were adopted within already distinguishable communities. Once religious affiliations were established, subsequent genetic signatures of the older differentiations were reinforced. Post-establishment differentiations are most plausibly explained by migrations of peoples seeking refuge to avoid the turmoil of major historical events.

Meanwhile, in Autosomal DNA

A like expansion and intensification of research interests has also transformed the field of Finnish DNA. In the old days it was well appreciated, through the work of Finnila and others, that the people of Finland, Estonia, Sweden and neighboring regions in Russia had a peculiar genetic history. Strangely, at least on the basis of mitochondrial DNA, they were more closely related to the Berbers of North Africa than the neighboring Swedes, Poles, Lithuanians and Russians. Female haplogroups UK were associated with a risk of occipital stroke, migraine and other neuro-deficiencies. On another level, their unique genetic history was approached through the study of male haplogroup N, common among Laplanders and Saami.

The focus has now shifted from haplotyping and sex-linked genes to population genetics and autosomal DNA just as it has in consumer tests. After 10 years, an important autosomal study of the Saami has revolutionized the subject and shows promise of becoming the pilot to a new series of genome-wide disease association studies.

A genome-wide analysis of population structure in the Finnish Saami with implications for genetic association studies

Jeroen R Huyghe et al. 

European Journal of Human Genetics (2011) 19, 347–352; doi:10.1038/ejhg.2010.179; published online 8 December 2010

Abstract

The understanding of patterns of genetic variation within and among human populations is a prerequisite for successful genetic association mapping studies of complex diseases and traits. Some populations are more favorable for association mapping studies than others. The Saami from northern Scandinavia and the Kola Peninsula represent a population isolate that, among European populations, has been less extensively sampled, despite some early interest for association mapping studies. In this paper, we report the results of a first genome-wide SNP-based study of genetic population structure in the Finnish Saami. Using data from the HapMap and the human genome diversity project (HGDP-CEPH) and recently developed statistical methods, we studied individual genetic ancestry. We quantified genetic differentiation between the Saami population and the HGDP-CEPH populations by calculating pair-wise FST statistics and by characterizing identity-by-state sharing for pair-wise population comparisons. This study affirms an east Asian contribution to the predominantly European-derived Saami gene pool. Using model-based individual ancestry analysis, the median estimated percentage of the genome with east Asian ancestry was 6% (first and third quartiles: 5 and 8%, respectively). We found that genetic similarity between population pairs roughly correlated with geographic distance. Among the European HGDP-CEPH populations, FST was smallest for the comparison with the Russians (FST=0.0098), and estimates for the other population comparisons ranged from 0.0129 to 0.0263. Our analysis also revealed fine-scale substructure within the Finnish Saami and warns against the confounding effects of both hidden population structure and undocumented relatedness in genetic association studies of isolated populations.

The key to emerging triumphs of research here is the international HapMap project.

On two fronts--religious history and rare diseases--genetics has brought more advances in the past decade than in the previous century before that. That consumers can take part in these exciting developments by ordering an affordable autosomal analysis of their entire ancestry or confirming the paternity of their child with a simple test purchased at their local drugstore is a tribute to the present golden age of American science and industry. 

Or At least Starting to Get Its Feet Wet

American Schools of Oriental Research Annual Meeting:
Tracking the Med's Stone Age Sailors

Andrew Lawler

Genetic studies are beginning to fill in the missing pieces in the history and prehistory of seafaring. "By carefully sorting genetic data from living people, a researcher at this recent meeting covered in Science reported that around 6000 B.C.E., early seaferers indeed spread their seed--both agricultural and genetic--from their homeland in the Near East as far west across the Mediterranean as Marseilles, but no farther."

No farther? Could that be because they have looked no farther?

Gunnar Thompson's new study, whose first print runs have already been exhausted apparently, Ancient Egyptian Maize, builds a well-documented and persuasive case that "Indian corn blossomed with equal vigor along the shores of the Nile River and Gulf of Mexico at the very dawn of history."

You may say that Gunnar Thompson is not a "real" researcher but we would counter that 400 corncobs on ancient tombs and papyrus scrolls of Egypt and corncobs depicted with copper weapons on ancient ships are real enough to be remarked upon by anyone with eyes in their head and a brain to think.

"Male regents in the Middle East and India sent mariners overseas in search of the world's purest copper deposits. These were located in the Mediterranean Sea on the Island of Cyprus, in the Persian Gulf on Megan Island, and on Isle Royale in the Upper Great Lakes Region of North America. This worldwide exploration took place in approximately 6000 B.C.E....all the way to the shores of North and South America" (p.2).

Jews and Muslims in Colonial America

After more than eight years in development, a book contract was awarded to Elizabeth Caldwell Hirschman and Donald N. Yates for their collaborative study of Crypto-Jews and Crypto-Muslims in the settlement of British North America. Titled Star, Crescent and Cross:  Jews and Muslims in Colonial America, the work will be published next year by McFarland, a leading U.S. publisher of scholarly, reference and academic books.

Among original investigations by the authors are genealogical studies of the West Country Gentlemen and others who proposed and promoted England's first colonies. From Sir John Hawkins (Sephardic Jewish surname Haquines, "physician" in Arabic) and Sir Francis Drake (whose family coat of arms bore a six-pointed star until it was air-brushed out by later historians) to Stephen Parmenius (a Jew from Turkish-held Hungary) and Captain John Smith, the principal players in England's colonization efforts are revealed to be far different from the white Anglo-Saxon Christian buccaneers American schoolchildren are taught about.

"England's reliance on Iberian Jews to promote its interests abroad goes back as far as the Tudors," according to Star, Crescent and Cross. "Henry VIII used Spanish Jewish lawyers to justify his divorce from Catherine of Aragon. One of them, an Italian banker tapped for his shrewdness and knowledge of international law, was the ancestor of Oliver Cromwell, Protector of the Commonwealth."

The book presents a series of colonial documents, contemporary firsthand accounts, records, portraits, family genealogies and ethnic DNA test results which fundamentally challenge the national storyline depicting America’s first settlers as white, British and Christian. The authors postulate that many of the initial colonists were of Sephardic Jewish and Muslim Moorish ancestry, usually arriving as crypto-Jews or crypto-Muslims.

Names Ordinary and Illustrious

The footnotes in the study document origins and meanings of over 5,000 surnames previously assumed to be sturdy English ones of ancient bearing. The authors' research casts a sidelight on celebrated Jewish Americans who can trace back to colonial forebears. These range from the Massachusetts Kennedys to the Byrds of Virginia, from actors Johnny Depp and Adrien Brody to actresses Roseanne Barr and Gwyneth Paltrow, from writers Louise Glück and Neil Simon to politicians Barbara Boxer and Bernie Sanders and jurists Stephen Breyer and Elena Kagan.

"We hope that the remarkable stories of the men, women and families in Star, Crescent and Cross will serve as a reminder of America’s early diversity and stimulus for rewriting some of the inaccurate and injudicious portions in the country's history," said Yates.

Among the famous colonial figures discussed (and usually illustrated with a portrait) are William Byrd II, Patrick Henry, William Bradford, William Penn, George Mason, George Washington, Richard Lee II, Thomas Paine, Paul Revere, Peter Stuyvesant, Luis Gomez, Jacob Troxell, Anthony Ashley Cooper Lord Shaftesbury, Tench Tilghman, Christopher Gist, John Skeen, Sir Philip Sidney, Walter Raleigh, Humphrey Gilbert, Virginia Dare, Don Luis de Carvajal, Daniel Boone, William Cooper, the Salem Witches, Christopher Gist, Lord Saye and Sele, and various Lowells, Cabots, Lodges, Livingstones, Delanceys and Roosevelts.

Chapter 2, "Sephardim in the New World" is a survey of Crypto-Jews in North America, especially the Caribbean and Atlantic Islands. It includes autosomal DNA data proving the Melungeons are probably descended from Jews mixed with American Indians, Africans and Gypsies/Romani, as recently reported in this blog. 

There are chapters and name-lists devoted to each of the original colonies. The book will contain over 50 illustrations.

English navigators and explorers included many West Country gentlemen. Most were from intermarried Crypto-Jewish families. New York Public Library.

 

Jewish I is described as "the most common of the three markers . . . its frequency highest in Poles, Russians, Germans, Hungarians, Romanians and Slavic peoples who intermarried with Ashkenazi Jews. It also appears in Italian, Spanish, Portuguese and Moroccan Jews (Sephardim)." This means it is a marker of general European admixture. But where is it most common, and where did the European Jews it identifies originate? Where were they concentrated in earliest times?

Statistical searches in ENFSI provide some tantalizing answers. Jewish I is found at a relatively high frequency throughout Europe but at elevated levels in Poland, Portugal and Belgium. It is lowest in Italy and Finland.

This would suggest that Jewish ancestry and intermarriage was common in countries where the population still carries this admixture marker.

Jewish II is characterized as the "strongest" marker, correlating very often with Ashkenazi Jewish parentage, especially in its double allele form (two checks under parents' columns on an 18 Marker Ethnic Panel or Jewish DNA Ancestry report). This description is validated by ENFSI results for 22 countries of Europe, where its strongest showings are in Czechoslovakia, Croatia and Slovenia (all Central European Slavic populations).

Its lowest frequency occurs in Germany, Denmark and the Netherlands, countries with few Ashkenazi Jews today. There are no data for Hungary in ENFSI since it does not belong to the European Union. Czech is the closest population in geography and historical composition. Likewise, there are no data for Slovakia, the southern part of the former Czechoslovakia, as Slovakia chose not to participate in ENFSI.

In Czechoslovakia, nearly 1 in 26 people carry Jewish II in its double allelic form, suggesting both parents were Jewish. The lowest frequency of Jewish II occurs in Scotland, where only 1 in 65 have it.

Note that even though most Ashkenazi Jews spoke Yiddish, a Germanic dialect, they were not necessarily German in origin. More likely they belonged to the Slavic peoples. Yiddish is not linguistically descended from Rhinish or Low German but a High German language of convenience adopted by Slavic-speaking Jews during Germany's medieval Drang nach Osten (Push to the East). Germany itself was considered a predominantly Slavic nation by geographers until the nineteenth century, when it was first unified under the Prussian monarchy.

The reason Jewish II is not detected at a higher level in today's German population is because of the ethnic cleansing and genocide committed by the Nazi government in the Second World War. For various reasons, Czechoslovakia and Hungary's Jewish populations, many of them assimilated Jews, survived better than Germany's.

The best book about German Jewry is probably The Pity of It All, A History of Jews in Germany, 1743-1933, by Amos Elon (Macmillan, 2002), although the author's approach to Jewish ethnicity is Zionist and doctrinaire.