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The Cherokee called them the Moon People. The Utes and Paiutes spoke of a hideous race of cannibals ten feet tall living in caves. And the Choctaw also have an account of the race of giants that first colonized the Ohio Valley. 

From Old World Roots of the Cherokee, chapter 5, "America's Middle Ages," pp. 78-79, we read:

What kind of Indians lived in the territory the Choctaw and Chickasaw carved out for their new home? According to their traditions, reports Cushman, as confirmed by excavations of bones in Tennessee, it was a “race of white giants”:

[T]he tradition of the Choctaws . . . told of a race of giants that once inhabited the now State of Tennessee, and with whom their ancestors fought when they arrived in Mississippi in their migration from the west, doubtless Old Mexico. Their tradition states the Nahullo (race of giants [literally, wizards]) was of wonderful stature; but, as their tradition of the mastodon [which used to be found on the Great Plains], so this was also considered to be but a foolish fable, the creature of a wild imagination, when lo! Their exhumed bones again prove the truth of the Choctaws’ tradition (151).

These giants could have been Rafinesque’s Atlans.

Cushman then recounts the discovery in 1880 at a burial mound site near Plano, Texas, of human bones “of enormous size . . . the femoral bones being five inches longer than the ordinary length, and the jaw bones . . . so large as to slip over the face of a man with ease.” Cushman goes on to identify them with the older occupants of North America called Allegewi or Taligewi (Talegans). Many historians, moreover, speculate they were the builders of the Adena mounds.

As for the Chickasaw, Cushman notes that they have no record of their history before the colonial period, although it is assuredly "the same as the Choctaws, being one tribe and people until the division made by their two chiefs Chikasah and Chahtah many years after their arrival and location east of the Mississippi River" (p 358). Of the Natchez, Cushman records that they, "if tradition may be believed, also came from Mexico where they had lived for centuries" (p 440).

A story was told by the Comanches in 1857: 

Innumerable moons ago, a race of white men, ten feet high, and far more rich and powerful than any white people now living, here inhabited a large range of country, extending from the rising to the setting sun. Their fortifications crowned the summits of the mountains, protecting their populous cities situated in the intervening valleys. They excelled every other nation which was flourished, either before or since, in all manner of cunning handicraft—were brave and warlike—ruling over the land they had wrested from its ancient possessors with a high and haughty hand. Compared with them the palefaces of the present day were pygmies, in both art and arms. They drove the Indians from their homes, putting them to the sword, and occupying the valleys in which their fathers had dwelt before them since the world began. At length, in the height of their power and glory, when they remembered justice and mercy no more and became proud and lifted up, the Great Spirit descended from above, sweeping them with fire and deluge from the face of the earth. The mounds we [i.e. the speaker Chief Rolling Thunder and his Spanish listener] had seen on the tablelands were the remnants of their fortresses, and the crumbling ruins that surrounded us all that remained of a mighty city.[i]

The word Nahoolo or Nahullo “is now emphatically applied to the white race and no other . . . The Nahullo were of white complexion, according to Choctaw tradition, and were still an existing people at the time of the advent of the Choctaws to Mississippi,” concludes Cushman (p 153) . In agreement, the Indian trader Adair often refers to the Nani Ishtahoolo as departed white ghosts vested with spiritual powers whose descendants were priests and magicians. Their cries and magic spells could still be heard in the mounds like those at Ocmulgee.[ii] These references contribute to the suspicion that the “Indians” who preceded Asiatic tribes from Mexico were, as we would say today, Caucasian.

About exactly a year ago on this blog, we published a post about "Neanderthals in America," mentioning also the peculiar archaic skeleton that is now a roadside attraction in Arizona, called The Thing. In the meantime, we acquired a copy of Fritz Zimmerman's book, The Nephilim Chronicles, which reproduces over 300 historical accounts of Giant skeletons. Many are associated with the earliest mound sites in America, but Zimmerman's survey of this worldwide phenomenon ranges from the Hunter-Fisher People of northeast Europe and Red Paint People whose movements were circumpolar to the giants of the Bible, noted by the Babylonian Talmud as having double rows of teeth, and "Giants' Remains in the British Isles" (pp. 157-65).

Navajo legends speak of the Starnake People, a regal race of white giants endowed with mining technology who dominated the West, enslaved lesser tribes and had strongholds all through the Americas. They were either extinguished or "went back to the heavens." The name may be a corruption of the Biblical race known as Anakim (Num. 13:33, Deut. 1:28). The name Og (Hebrew "chief") appears to be characteristic (see Zimmerman, pp. 188-91). The ogham alphabet is attributed to this cultural founder. 

Certainly, many of the mound sites uncovered in the nineteenth century tell a story of constant warfare by incoming Asiatic tribes  against the giants occupying the land. One grisly scene showed thousands of skeletons, male, female and young heaped in a mass grave, with warriors' skulls pierced by arrows. It would appear that as these aboriginal inhabitants of the Ohio Valley were gradually displaced, some members of their society went over into the ranks of the new conquerors, bequeathing a strain of great stature still noticeable, for instance, in the Mobilian chief Tuscaloosa and DeSoto's Indian queen Cofitachiqui, both of whom were said to be seven feet tall.

We are struck by the following traits of this giant race or ethnic group from human prehistory:

• Mother Goddess religion
• Copper (not bronze) axes 
• Polished slate tools including fishing plummets, which were apparently regarded as sacred
• Belief that the Grandmother Moon was the repository of souls
• Diet emphasizing shellfish (for which the double row of teeth probably was selected as an evolutionary advantage in their beachcomber origin out of Africa?)
• Building of fish weirs in North American rivers to trap migrating eels
• Certain vegetarian habits (wild rice, for instance)
• Inscriptions on artifacts, especially pipes, often buried with the dead
• Use of coal and petroleum
• Weaving and looms
• Knowledge of seafaring, mathematics and engineering, including canals and irrigation
• Burying of a dog with a child to guard the latter in the afterlife
• A language apparently Afro-Asiatic and close to Semitic tongues
• Kingcraft:  nobles were buried in seated positions on thrones surrounded by a coterie of their retainers

Yes, according to Bill Tiffee, whose article on Solutreans in America will appear in volume 29 of the series Epigraphic Society Occasional Papers. Titled "Were Ancient Egyptians the Solutreans Who First Settled America?" the new study, he says, "looks at the possibility that the Solutreans who first settled America were from Egypt, and that the genetic marker X is found in the highest concentrations among the Druze (who migrated from Egypt 1,000 years ago)and the descendants of the Moundbuilder Native groups including the Sioux and Algonquin and possibly the Cherokee."

We have previously suggested that the Cherokee incorporate both Greek and Egyptian DNA. Chapter 3 of Donald Yates' new book Old World Roots of the Cherokee is devoted to the DNA story of the so-called "anomalous" Cherokee lines, including haplogroups T and X. 

Several prominent scholars have argued that Europeans known to archeologists as the Solutreans of France and Spain around 18,000 years ago were the first to settle the Americas. Tiffee examines the similarities between Solutrean and Clovis or Paleo-Indian stone technology and reconstructs the Solutrean culture in Egypt beginning 24,000 years ago (p. 119). He links ancient Egyptians with genetic marker E-M78, mitochondrial haplogroup X, Tula and the Spiro Complex mounds in Oklahoma, among other North American sites. He also discusses the Great Flood of about 10,000 years ago, the legends surrounding Osiris and the rise of agriculture in southern Turkey (Gobekli Tepe). 

"Perhaps," he concludes, "Egyptologists need to rethink their paradigms of ancient Egypt. And perhaps modern Native American descendants of the Moundbuilders, the Algonquin groups, Sioux, Cherokee, Chickasaw (and other Native cultures closely related to mound-building) need to reconsider where their most ancient ancestors came from (129)."

In DNA Consultants' Cherokee DNA study, "Anomalous Mitochondrial DNA Lineages in the Cherokee," as well as numerous blog posts since 2009, it was reported that haplogroups U, T, K, J, N, X and L are found in Cherokee descendants in frequencies mirroring those of Egypt.