DNA Consultants Home of the DNA Fingerprint

New Center is Hiring

The University of North Carolina at Chapel Hill dedicated its new Genome Sciences Building on University Day, Oct. 12, 2012, a major event in the increasingly interdisciplinary world of genome science. Located at the geographical center of campus, the Genome Sciences Building has an overarching goal: to foster collaborations at the intersection of different disciplines – and in every way, it is designed to do just that, according to the university.

“Proximity is really important in a busy world,” says Jeff Dangl, Howard Hughes Medical Institute investigator and John N. Couch Professor of Biology. “The explicit concept of this building is let’s hire new people at the interface of all of our traditional disciplines. Let’s give them a home – or at least a foothold – here in this building and see what comes of it in terms of generating new synergistic science.”

Symbolically, the building's footprint lies on the border between the College of Arts and Sciences and the five health affairs schools, where basic research meets clinical applications. Researchers from departments as diverse as biology, chemistry, computer science and statistics have opportunities to interact with each other in the building and are very closely located to colleagues in the schools of medicine, pharmacy, nursing, dentistry, public health, and information and library science.

DNA Consultants' founder and chief research officer, Donald Yates, has a Ph.D. from the University of North Carolina at Chapel Hill. We applaud the new center's interdisciplinary mission and bridging of sciences including the campus' traditional strengths in statistics, computer and library science.

In 2012, UNC rose to 9th in the nation for federal funding devoted to research and development. The current level of $546 million during fiscal 2010 is spread among all fields and puts the university fourth among public campuses in the country. 

One of the projects supported by such research was the Cancer Genome Atlas program led by Carolina's Charles Perou, professor of molecular oncology. Perou's team published their work in the journal Nature and opened the way to personalized treatment of breast cancer, as widely reported in the media, including the front page of the New York Times. 

Among the explosive stories in Sam Kean's excellent "biography" of DNA, The Violinist's Thumb (Little, Brown, 2012), is a chapter on what makes mammals mammals. The short answer is a placenta, and Kean begins by discussing a rare case of mother and daughter coming down with a hereditary form of leukemia, a sort of "simultaneous cancer." 

The chapter is titled "Love and Atavisms," and it zeroes in on the role of the major histocompatibility complex in the origin of mammals and selection of sex partners. MHC is the factor that makes some potential mates smell better than others to females (through pheromones). In one experiment, women were given tee shirts males slept in to smell, and they identified the "wildest" smelling as the most attractive. Same smelling T shirts were spurned, perhaps for the same reason members of our own nuclear family are not sexy-seeming to us. (In places with little genetic variety, like Utah, it was shown that pheromone sensors were inoperative.)

"In humans, MHC is located on the shorter arm of chromosome six (p. 169)." In the case of the infant born with her mother's congenital proneness to leukemia, the cancer cells had deleted her MHC. She developed acute lymphoblastic leukemia, eventually being successfully treated for it, although her mother died of it in the same timeframe.

"We don't think of cancer as a transmissible disease," Kean writes. "Twins can nevertheless pass cancer to each other in the womb; transplanted organs can pass cancer to the organ recipient; and mothers can indeed pass cancer to their unborn children, despite the defenses of the placenta (p. 176)."

But now comes the truly amazing revelation.

"Other scientists have painstakingly determined that most if not all of us harbor thousands of clandestine cells from our mothers, stowaways from our fetal days that burrowed into our vital organs. Every mother has almost certainly secreted away a few memento cells from each of her children inside her, too. Such discoveries are opening up fascinating new facets of our biology; as one scientist wondered, 'What consitutes our psychological self if our brains are not entirely our own?' More personally, these findings show that even after the death of a mother or child, cells from one can live on in the other. It's another facet of the mother-child connection that makes mammals special." (pp. 176-77)

Thus female DNA lives on down the ages, while male DNA shows a fragile character and is doomed to experience dead ends. Siblings may get different "clandestine" cells from the same mother and develop different heteroplasmies, accounting in part for their different personalities, abilities and family traits.



Listen to an in-depth interview with Sam Kean by Terry Gross on NPR's "Fresh Air"