DNA Consultants Home of the DNA Fingerprint

Will explore theme of official and unofficial ethnic self-identification from perspectives of genetics, marketing and other disciplines

A team of professors has just submitted a proposal for a 90 minute panel discussion at the 12th International Diversity Conference in Vancouver, B.C., June 11-13, 2012.

We'll use this blog to announce updates and you may place comments here and link to it.

Title:
Perspectives on Ethnic Identity: Epigenetics, Marketing, DNA and Genealogy

Panelists:
Donald N. Yates, DNA Spectrum
Dr. Anne Marie Fine, Fine Natural Medicine
Elizabeth Caldwell Hirschman, Rutgers Business School
Teresa A. Panther-Yates, Paradise Valley Community College, Phoenix
Wendy D. Roth, University of British Columbia
Phyllis E. Starnes, DNA Consultants

Description
Genetics has transformed many of our notions of race, ethnicity and identity. How do people in North America's melting pot of emigrants admixed with indigenous and African slave descendants self-identify when naming their primary and ancillary ancestries for official and unofficial purposes? The fundamental question of who you are and what you claim to be will be raised from the perspectives of marketing and consumer studies, sociology and direct-to-the-consumer DNA testing, genealogy (with a focus on the ethnic group known as Melungeons), epigenetics and medical marketing, and the special case of American Indian Descendants and Partial Descendants.

Stream: Identity and Belonging; the Politics of Diversity; Globalisation
Presentation Type: 90 minute Colloquium in English

Geneticists seized the opportunity provided by an international Basque cultural event held in Idaho in 2010 to sample volunteers and study Basque DNA. The result was two studies, including "The Y-STR Genetic Diversity of an Idaho Basque population, published in Human Biology.

It was the first DNA study to document the spread of the Basque male chromosome overseas. The Basque people were renowned seafarers.

"The idea is to better understand health risks for Basque people, including an increased incidence of both Alzheimer's and Parkinson's diseases," said Josu Zubizarreta, a Boise State graduate who conducted research with the lead author, Greg Hampikian.

Mitochondrial DNA, which reflects a deeper history, was also studied.

Basques are credited with the invention of the rudder. They provided the crew and navigators for Magellan. Basque names are common on antique maps. The Bay of Biscayne is named for them, and many harbors, points and landfalls on the Atlantic Coast of North America are thought to come from the Basque language, which is known as an isolate and is unrelated to other European languages.

Sculpture of Basque sailor, Victorio Macho, Toledo. Travelpod.

Citation
Zubizarreta, Josu; Davis, Michael C.; and Hampikian, Greg (2011) "The Y-STR genetic diversity of an Idaho Basque population, with comparison to European Basques and US Caucasians," Human Biology: Vol. 83: Iss. 6, Article 2.
Available at: http://digitalcommons.wayne.edu/humbiol/vol83/iss6/2

Everyone probably has wondered at some time what makes Aboriginal Australians different from other people, where they came from and how old their ethnic type is. Well, wonder no more. Following up on the previous post, "Australian Aboriginal DNA Gets Attention," this post will summarize the groundbreaking article in Science magazine, M. Rasmussen et al., "An Aboriginal Australian Genome Reveals Separate Human Dispersals into Asia" (Science 334, 7 Oct. 2011, 94-98).

First the abstract:

We present an Aboriginal Australian genomic sequence obtained from a 100-year-old lock of hair donated by an Aboriginal man from southern Western Australia in the early 20th century. We detect no evidence of European admixture and estimate contamination levels to be below 0.5%. We show that Aboriginal Australians are descendants of an early human dispersal into eastern Asia, possibly 62,000 to 75,000 years ago. This dispersal is separate from the one that gave rise to modern Asians 25,000 to 38,000 years ago. We also find evidence of gene flow between populations of the two dispersal waves prior to the divergence of Native Americans from modern Asian ancestors. Our findings support the hypothesis that present-day Aboriginal Australians descend from the earliest humans to occupy Australia, likely representing one of the oldest continuous populations outside Africa.

Above:  Aboriginal Men about 1900 from the Coranderrk Community. La Trobe Picture Collection.

This study of Aboriginals will be cited as a landmark case in genetics because the authors took especial care to disarm any criticism concerning possible admixture and contamination, achieved a stupendous rate of success in sequencing DNA sites and used smart comparators to verify their model of what makes Aboriginals different, including Neanderthals, Denisovans, Andamanese, Filipinos, Indians, Papua New Guineans and Melanesians. Fifty-eight co-authors are listed, with Morten Rasmussen of the Feinstein Institute for Medical Research, Manhasset, New York, named as the first lead author.

First sentence:

The genetic history of Aboriginal Australians is contentious but highly important for understanding the evolution of modern humans.

Some mysteries pointed out about Aboriginal Australian DNA by the authors include:

--The Aboriginal population contains a lot of diversity, including specimens of most of the world's haplogroups, male and female

--Related populations suggested are hunger-gatherers from Nepal and the Philippines, Great Andamanese and Onge from the Andaman Islands, Highland Papua New Guineans and certain peoples from India

--It was previously unclear whether Aboriginals resulted from a single dispersal out of Africa or multiple-dispersal model

--The role of hybridization with other archaic peoples was also not clear.

The authors confirm that "before European contact occurred, Aboriginal Australian and PNG Highlands ancestors had been genetically isolated from other populations (except possibly each other) since at least 15,000 to 30,000 years B.P." Also, "our results favor the multiple-dispersal model in which the ancestors of Aboriginal Australian and related populations split from the Eurasian population before Asian and Europeans split from each other" (97). "We find that the European and Asian populations split from each other only 25,000 to 38,000 years B.P., in agreement with previous estimates."

The new study finds that Aboriginals have an amount of admixture with Neanderthals and Denisovans comparable to Europeans and Asians, although they have more Denisovan DNA than other people. "This admixture may have occurred in Melanesia or, alternative, in Eurasia during the early migration wave" (97).

In sum, the Aboriginals are part of the same first-out-of-Africa branch of the human tree as Europeans and Asians, their ancestors splitting 62,000 to 75,000 years ago from Africans, and leaving relic related populations in the Highlands of Papua New Guinea and the Philippines. A second expansion wave through India, Indo-China and Southeast Asia replaced the original stock, while the Aboriginals became stranded and isolated in Australia about 50,000 years ago. 

"This means that Aboriginal Australians likely have one of the oldest continuous population histories outside sub-Saharan Africa today" (98).

Properly positioning Australian Aboriginals in the expansion of humans out of Africa opens the way to connecting the dots for all the other prehistoric peoples. The migration map presented by Rasmussen et al should be carefully studied for clues about the origins of Asians and Native Americans, to begin with.



Reconstruction of early spread of modern humans outside Africa. Note admixture between early dispersal (red) and second dispersal (black), as well as presence of archaic Denisovans in Asia. Science magazine.

San Diego State University professor D. Emily Hicks has traced some common ancestry with President Barack Obama. According to the professor of Chicana/o Studies, she and the President share Melungeon roots. Obama is a descendant of Mary Collins of Orange County, Virginia as well as of Nathaniel Bunch of Louisa County and John Bunch of New Kent--well known "feeder" counties for what became the Melungeon settlement described in Brent Kennedy's book, The Melungeons, The Resurrection of a Proud People.

Obama's Bunch line was found to carry E1b1a haplogroup, a sub-Saharan African male lineage. He is also supposed to have Cherokee ancestry in his mother's colonial genealogies.

Read the whole story at PRLOG.

Phyllis Starnes drew many threads of Melungeon research together when she delivered her presentation on autosomal DNA validation studies at the Fifteenth Melungeon Union, held atWarren Wilson College, Swannanoa, NC July 15-16, 2011. Sponsored by the Melungeon Heritage Association of Kingsport, Tenn., the conference was appropriately titled, "Carolina Connections: Roots and Branches of Mixed Ancestry."

Starnes, who is administrator of DNA Consultants' Melungeon DNA Studies as well as an assistant investigator responsible for authoring reports, began her presentation by telling her own story. In 2002, she read an article about the occurrence of Familial Mediterranean Fever in Appalachia, where she grew up. "This article was the catalyst for me to address my own health and ancestry," she told participants.

She had met N. Brent Kennedy, author of the touchstone book The Melungeons:  The Resurrection of a Proud People, and soon became acquainted with both Elizabeth Hirschman (Melungeons:  The Last Lost Tribe in America) and Donald Panther-Yates, both speakers at Melungeon Fourth Union in Kingsport. The resources she needed for understanding her peculiar heritage were coming together.

Starnes summarized the Hirschman-Yates study of Melungeon DNA results published last December in Appalachian Journal and went on to reveal the results of a validation study of the Melungeon data in which the DNA profiles of the 40 participants were fed back into the database atDNA, expanded to reflect the world's only autosomal DNA Melungeon sample.

Astoundingly, many Melungeon DNA project participants had Melungeon as their No. 1 match, including Starnes.

In 1990, physical anthropologist and chemist James Guthrie analyzed blood sampled from 177 Southern Appalachian people identifying as Melungeon tested by Pollitzer and Brown in 1969. Guthrie's analysis was consistent to a remarkable degree with the Hirschman-Yates study.

All studies to date have verified and confirmed repeatedly that Melungeon descendants carry an unusual mix of Jewish, Mediterranean, Turkish, Iberian, Native American and African DNA. They also inherit genetic predispositions toward developing Familial Mediterranean Fever and other disorders.

This overarching thesis explaining what makes Melungeons different was advanced over twenty years ago by Brent Kennedy. It has now been re-examined, probed, tested and validated by unimpeachable followup studies, but little has turned up to change Kennedy's original thinking. It would be wrong to say that Melungeon origins today are controversial or mysterious. There is much we do not know about them, but their genetic and medical profiles are clear.

Starnes is enrolling people in Phase II of the Melungeon DNA Study. She has also inaugurated a password-secured blog where participants can freely share their experiences.

DNA Consultants' fourth Jewish marker, Tatar/Khazar, has been renamed Jewish IV, bringing it into line with European, Asian and Sub-Saharan African marker groups. All these populations have four markers in acknowledgment of their complexity, age and diversity.

Native American has only two markers.

Jewish IV can be expected to be more sensitive following the addition of Altai Turkic, Caucasus, Southern Russian and Khazak population data to the company's computer program atDNA.

The four Jewish markers may be described as follows:

JEWISH I. This is the most common of the three markers. It can occur without known Jewish ancestry for a variety of reasons including an ancestor’s conversion to Christianity during the centuries of persecutions against Jews in Europe. Its frequency is highest in Poles, Russians, Germans, Hungarians, Romanians and Slavic peoples who intermarried with Ashkenazi Jews. It also appears in Spanish, Portuguese and Moroccan Jews (Sephardim).

JEWISH II. This marker is the strongest. It is found in Jewish families who have intermarried with other Jews down through the centuries. It is characteristic of Ashkenazi Jews.

JEWISH III.  This marker is an indication of Middle Eastern roots. Preserved by Jews, it is also borne by Kurds, Syrians, Arabs, Berbers, Basques, Turks, Greeks, Italians and other populations from the ancient world.

JEWISH IV. A marker indicative of Tatar or Khazar heritage. Khazars were a Central Asian people of Turkic, Hunnish and Iranian elements that arose in the Caucasus region. After converting to Judaism in the early Middle Ages, they moved westward into Russia and the Ukraine under pressure from Islam, eventually becoming a large component of Eastern and Central European Jewry. Many Ashkenazi Jews now find they have some Khazar (or intermingled Tatar) ancestry.

As can be seen, these divisions reflect the three major convert populations of Judaism, Sephardim, Ashkenazim and Khazars (often referred to as "the thirteenth tribe") in addition to the original Middle Eastern Israelites and related people of the Bible (Jewish III), which forms the core genetic element of solidarity.

Khazar rabbis.

"There are already many fine books on the history of the Jews in the Middle Ages," writes Theodore L. Steinberg, an English professor at State University of New York, in the preface to his Jews and Judaism in the Middle Ages (Wesport:  Praeger, 2008). So why another one?

"All of those other studies, as excellent as they are, presume a certain degree of knowledge on the part of the reader--knowledge of Jewish customs and traditions and beliefs, as well as a general knowledge about the Middle Ages," he continues.

If you have never been to a synagogue service, don't know many observant Jews and perhaps just discovered an interest in Judaism after finding Jewish ancestry in your family tree, this is the book for you. Beginning with the first chapter, "Jews and Judaism, What Are They? and continuing with "Talmud and Midrash," Steinberg skilfully guides the reader through a crash course on Jewish history since the advent of Christianity. He introduces us to the rabbinical traditions of Judaism, Mishan, Gemara and all the flowering branches of halakah or Jewish law. We learn why Jews were blamed, and tolerated, by the Church. We learn about everyday life in cities where Jews, Christians and Muslims mixed, Jewish occupations, their literature, philosophy and the Cabala, all major areas of intersection with Christian society. 

Appendix I has a good chronology of important events, from the life of Rabbi Akiva, which overlapped with that of Saul/Paul to the infamous date of 1492.

Singular Figure of Joseph Jacobs

Another masterwork on Judaism intended primarily for non-Jewish readers is Joseph Jacobs' Jewish Contributions to Civilization. An Estimate (Philadelphia:  Jewish Publication Society of America, 1919). This began life as the Australian Judaic scholar's Studies in Jewish Statistics, published in an anthropology journal in 1891, at the height of his fame. It was to be the first volume in a trilogy, the second book devoted to individual, rather than collective, contributions to European culture, the third a philosophical answer to anti-Semites about the value of Jews in the modern secular state. Alas, Jacobs died in 1916, leaving only notes for the second book and nothing at all of the third.

For Jacobs the watchword is always "judicious." He never exaggerates Jewish influence, emphasizing again and again that the number of Jews at no time, probably, rose above one-half of one percent in Western Europe, outside of countries where Jews were tolerated such as Moorish Spain and Poland/Lithuania under the Jagellon dynasty.

Did Jewish thinkers transform medieval philosophy from the stale dogmas of the theologians into more modern ideologies? Maybe, but they were only part of the movement.

His considered assessment of the Jewish contribution to medieval fables and folklore, one of his academic specialties, is "about one-tenth" of the material. There are those today, however, who would go so far as to say all of troubadour poetry and half of courtly love romances were inspired by the Judeo-Arabic tradition of Spain and southern France, with deeper roots in Arabia, Egypt and Babylon.

Did the Radanite ("From Persian rah dan, knowing the way") merchants plying the Silk Road in the early Middle Ages introduce all the choice import goods and enlightened ideas we associate with the East?

Europe owes to the Jewish Radanites the introduction of oranges and apricots, sugar and rice, Jargonelle pears, and Gueldre roses, senna and borax, bdellium and asafoetida, sandalwood and aloes, cinnamon and galingale, mace and camphor, candy and julep, cubebs and tamarinds, slippers and tambours, mattress, sofa, and calabash, musk and jujube, jasmine and lilac " (p. 203)

But their influence was limited. Beginning in the twelfth century, Venice took away the monopoly on the Levantine trade, just as Lombard merchants replaced Jews as bankers and moneylenders throughout most of Europe. The transition to a moneyed economy, according to Jacobs, was not due to Jews.

On the subject of Jews and capitalism, including stock exchanges and paper money, Jacobs takes a Ciceronian position. He denies that any Jews were involved with the South Sea Bubble, Mississippi Scheme of John Law or other experimental business models of the day. He does not even think that Jews fostered acceptance of bills of exchange or letters of credit. He points out that even with the Dutch East India Company, Jews had only very moderate ownership (although we wonder if like the silent partner behind the usurious kings of medieval times the partners named Coen and Hendricks and the like chose rather to have their names out of it), while the Jewish presence was absent at the first exchanges in Antwerp and London, and later minimal.

We think he might be too circumspect here. The Jewish role in the discovery, exploration and development of the American colonies is set forth in detail in Elizabeth C. Hirschman and Donald N. Yates, Jews and Muslims in British Colonial America (Jefferson:  McFarland, forthcoming this fall). 

Jacobs is particularly harsh toward his contemporary Werner Sombart, who wrote an enthusiastic and eulogistic apology for the Jews in economic history (Die Juden und das Wirschaftsleben, Leipzig, 1911, trans. by M. Epstein, 1913, The Jews and Modern Capitalism). Jacobs calls the European professor of economics' work a "farrago of fantasies about Jewish life and religion" (259). The dour Victorian explicitly rejects Sombart's equation of the American way of business with Jewish practice and influence ("what we call Americanism is nothing else than the Jewish spirit distilled"). Again, however, we think Jacobs is bending over backward not to appear partisan. His objections to Sombart's arguments seem academic and petty if Sombart was on the right track, as most people concede today.

Prudent or Prudish?

In the same way, we feel that Jacobs' inability to detect any Jewish influence in the Puritans, or indeed the entire Reformation, is willfully blind.  "It cannot be by chance," he writes, "that the three most prominent voices among the Politiques [advisors to French king Henri IV], who laid down the principles which were to result in the Edict [of Nantes, granting toleration to Protestants, 1598]-- Michel de l'Hopital, Jean Bodin and Michel de Montaigne--were all partly of Jewish race" (p. 281). But what he gives with one hand Jacobs takes away with the other, for he goes on to say that the influence of these men stopped with the borders of France, while "freethinkers" in other countries like Spinoza certainly did not meet with much success.

And of course, looking ahead to the eventual playing out of these policies, we cannot attribute either the American Bill of Rights or French Revolution to Jews, can we?  Jacobs has a bowdlerized version of Jewish influence. He is willing to take modest credit for the good things Jews introduced, while letting their Christian imitators line up in the limelight and get the glory, but he doesn't want to admit that Jews might have been responsible for or at least complicit in some evils in modern society, such as communism, the militaristic state and free love ("the sexual vagaries of Enfantin," p. 308).

As Revealed by Autosomal Markers

No scientific work, to our knowledge, has ever hazarded a guess on what the mutation rate for autosomal CODIS-type markers might be. Is it like mitochondrial DNA, which has a molecular clock measured in the thousands or tens of thousands of years, or is it like STRs on the Y chromosome, with its much shorter timeframe? The question is important if you are trying to extrapolate the history of the human race from today's autosomal population statistics.

From what we can see, putting on diachronistic lenses, the mutation rates for the DYS values on what are commonly called CODIS markers or the DNA profile for individuals are very small. The values appear to have been set from the beginning of mankind and to have mutated little in the past 100,000 years.

If this is true -- and it cannot be a very big "if" or we would have more diversity between populations than what is known -- the oldest markers are Sub-Saharan African and the newest European. Statistical divides bear out this reading of the human genetic record, as shown now in our updated map included with the DNA Fingerprint Plus.

We will try to make some notes on the individual markers in future posts.

If you think haplogroup testing for Native American DNA is in sad shape, you should look at autosomal testing. It has been practically nonexistent. Even the major 2007 study by Wang et al. has glaring gaps and methodological quandaries(1).

DNA Consultants' newest autosomal product is the Native American DNA Fingerprint Plus based on 21 published studies of Native American population groups as well as informal customer data. Results for many individuals were validated with older haplotyping methodology.

There were data for 3,583 Native Americans available in development of the product. These test results came from articles published between 1997 and 2009. They included individuals identifying with tribes or nations as follows:

Apache
Athabaskan
Huichol
Inupiat
Kichwa
Lumbee
Navajo
Salishan
Yupik

The following geographical areas were represented:

Alaska
Arizona
Brazil
British Columbia
Colombia
Ecuador
Florida
Guatemala
Mexico
Michigan
Minnesota
North Carolina
Oklahoma
Ontario
Saskatchewan

Nothing labeled as Cherokee -- the largest Native group in the U.S., with more than 400,000 representatives -- has ever been tested. Anecdotally, people of Cherokee descent often receive matches to North Carolina or Michigan Native Americans. The reason for the latter matchup is obscure. North Carolina as the Cherokee's original homeland makes a lot more sense.

1. Wang, S. et al. (2007). “Genetic Variation and Population Structure in Native Americans.” PLoS Genetics 3/11 (with good bibliog.):  http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0030185.

This posting will review some of the material we have previously made available about the science behind our three Jewish markers in the autosomal 18 Marker Ethnic Panel. First, it may be worthwhile to recount the chronology of our testing innovations in this area.

2006 - DNA Consultants introduces the DNA Fingerprint Test, one of the first simple autosomal ancestry tests based on population databases

2009 -Donald N. Yates, Ph.D., principal investigator, makes the discoveries in July that lay the foundation for the DNA Fingerprint Plus, rolled out in early September. The enhanced product includes simple autosomal markers for Native American, European, Jewish, Asian and African ancestry, based upon their frequencies of occurrence in these ethnicities.

2010 - Several important studies on Jewish genetics appear; DNA Consultants introduces Jewish DNA Test

2011 - DNA Consultants releases version 2.0 of its autosomal population database atDNA, marking the addition of the population Melungeon (n=40).

One of the first of the Jewish markers to be blogged about was Jewish II, characteristic of Ashkenazi Jews. Theodor Herzl, the nineteenth-century Austro-Hungarian Zionist thinker-organizer who helped inspire the founding of the State of Israel, is an example of a famous Ashkenazi Jew. There was another post titled Jewish Marker II Statistical Notes.

A post on Jewish I soon followed, together with a discussion about its European connections. There has been an ongoing discussion on the Jewish Forum on DNA Communities.

Jewish III has been the slowest to emerge. Its Middle Eastern nature has been explored and expanded upon in several threads on DNA Communities.

In the Fall of 2010, our project administrator tabulated results for more than 450 people who had ordered a Jewish Ancestry Test through our partner Jewish Voice. It was found that 99.97% showed at least one Jewish marker, that is, had some Jewish ancestry.  Some had all three markers while others had a combination of the three in some way.  The informal study indicated 74% of Jewish Ancestry Test takers had Jewish I, 30% had Jewish II and 82% Jewish III.