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Geneticists seized the opportunity provided by an international Basque cultural event held in Idaho in 2010 to sample volunteers and study Basque DNA. The result was two studies, including "The Y-STR Genetic Diversity of an Idaho Basque population, published in Human Biology.

It was the first DNA study to document the spread of the Basque male chromosome overseas. The Basque people were renowned seafarers.

"The idea is to better understand health risks for Basque people, including an increased incidence of both Alzheimer's and Parkinson's diseases," said Josu Zubizarreta, a Boise State graduate who conducted research with the lead author, Greg Hampikian.

Mitochondrial DNA, which reflects a deeper history, was also studied.

Basques are credited with the invention of the rudder. They provided the crew and navigators for Magellan. Basque names are common on antique maps. The Bay of Biscayne is named for them, and many harbors, points and landfalls on the Atlantic Coast of North America are thought to come from the Basque language, which is known as an isolate and is unrelated to other European languages.

Sculpture of Basque sailor, Victorio Macho, Toledo. Travelpod.

Citation
Zubizarreta, Josu; Davis, Michael C.; and Hampikian, Greg (2011) "The Y-STR genetic diversity of an Idaho Basque population, with comparison to European Basques and US Caucasians," Human Biology: Vol. 83: Iss. 6, Article 2.
Available at: http://digitalcommons.wayne.edu/humbiol/vol83/iss6/2

Gene surfing is a process in population expansion whereby certain variations become prominent and dominant in a short time, appearing to skip the slow, steady, uniform accumulation of variegation and diversification. According to a study of the population structure and genealogies of Saguenay Lac-Saint-Jean in Quebec, this type of drastic change accompanied the immigrant wave front that spread over the area in the 17th century. "Deep Human Genealogies Reveal a Selective Advantage to Be on an Expanding Wave Front" in Science magazine describes the resulting demographics.

Abstract
Since their origin, human populations have colonized the whole planet, but the demographic processes governing range expansions are mostly unknown. We analyzed the genealogy of more than one million individuals resulting from a range expansion in Quebec between 1686 and 1960 and reconstructed the spatial dynamics of the expansion. We find that a majority of the present Saguenay Lac-Saint-Jean population can be traced back to ancestors having lived directly on or close to the wave front. Ancestors located on the front contributed significantly more to the current gene pool than those from the range core, likely due to a 20% larger effective fertility of women on the wave front. This fitness component is heritable on the wave front and not in the core, implying that this life-history trait evolves during range expansions.

So gene surfing in an expanding colonization phase can produce a genetic revolution whose effects will be felt for hundreds or thousands of years downstream in history.

We wonder if the same wave front demographics might explain some of the following population phenomena:

• Large scale triumph of Norman male lineages following the conquest of England in 1066.
• Selective expansion of Middle Eastern genes in Tennessee (including Cherokee families, Jewish male and female lines and Melungeons)
• Relatedness among Jews and "Jewish diseases"
• Diversity-within-uniformity of Polynesians
• Population replacement of Old European (U, N) by Middle Eastern genes (T, J)  in Europe as a result of the Neolithic Agricultural Revolution

Many students of history are puzzled why old populations have the allele frequencies and heterozygosity clines they have. Genetic drift is only part of the answer. Gene surfing and selection in deep history are the rest of it.

According to a professor of immunology and microbiology at Stanford University, humans were able to survive, spread and expand their populations once they left Africa because of immunities to disease they acquired from Neanderthals and Denisovans, who had lived in Europe and Asia already for hundreds of thousands of years.

A review of the new research appears in the online science magazine Discover under the date of June 20, 2011. The professor's name is Peter Parham.

Crux of the matter, according to Royal Society report

• Parham began by taking a close look at a family of genes called  human leukocyte antigens (HLAs), which play a central role in our body’s immune responses. We are able to react to a wide array of diseases because our HLA genes are highly variable, each containing dozens of  alleles (forms of genes).
• Our ancestors in Africa, however, would have had a small number of HLA alleles because they likely traveled in small bands and had little contact with other groups. Moreover, their HLAs would have only protected them against African diseases.
• When Parham compared the HLAs of modern humans with those of Neanderthals and Denisovans, he noticed some overlaps. In particular, he found that HLA-C*0702, an allele common in Europeans and Asians but nonexistent in Africans, was also present in the Neanderthal genome. Similarly, HLA-A*11, which is found in modern Asians but not in Africans, popped up in Denisovan DNA.
• Overall, about 50 percent of HLA Class I alleles in Europeans seemed to come from Neanderthals, 70 to 80 percent in East Asians from Denisovans, and 90 to 95 percent in Papuans from Denisovans, Parham said at a recent Royal Society meeting.

The latest revelation about the true nature of Neanderthals shows how fast current scientific and popular thinking is moving on the subject. Two years ago it was still debated whether "humans" could interbreed with Neanderthals, or whether Neanderthals were even a human species. Denisovans were only discovered in the last year.

DNA Consultants introduced its Neanderthal Index, a measure of affinity with archaic populations of Europe and the Middle East, one year ago this month.

Dr. Donald Yates says he is planning a visit to Vindija cave near Varazdin in Croatia this month to see firsthand the world's most important site for the discovery of Neanderthal bones and lifeways, dating to about 30,000 years ago.

Human history changed drastically with the 1974 Neanderthal discoveries at Vindija Cave. Photo Tomislav Kranjcic.

Did Neandertals Linger in Russia's Far North?

By Michael Balter

Science 13 May 2011:
Vol. 332 no. 6031 p. 778
DOI: 10.1126/science.332.6031.778

For more than 150,000 years, Neandertals had Europe's lush river valleys to themselves. Then, beginning about 40,000 years ago, modern humans swept in from Africa and the Near East, spreading rapidly from east to west. Soon, the archaeological evidence suggests, the Neandertals retreated to “refugia” in southern Europe, such as Spain and Portugal—their last holdouts before going extinct.

Or were they? On page 841, a research team claims that some of the last Neandertals may have taken refuge in the dark Arctic north rather than the sunny south. At the 32,000-year-old site of Byzovaya in Russia's Polar Ural Mountains, which at 65 degrees latitude is as far north as Iceland, archaeologists found stone tools they argue are typical of those long associated with Neandertals in Europe...

Read abstract.

Note: This may explain why Finno-Uralic is one of the strong contributors to a high score on our Neanderthal Index.

Byzovaya Cave in Russia's Polar Ural Mountains with Neanderthal artifacts.

Human origins: Shadows of early migrations

By Carlos D. Bustamante & Brenna M. Henn


Nature Volume: 468, Pages:1044–1045
Date published:(23 December 2010) DOI:doi:10.1038/4681044a
Published online22 December 2010

Analysis of ancient nuclear DNA, recovered from 40,000-year-old remains in the Denisova Cave, Siberia, hints at the multifaceted interaction of human populations following their migration out of Africa.

The new discipline of palaeogenetics is delivering increasing dividends, the latest news coming from Reich, Pääbo and colleagues on page 1053 of this issue. The authors' analysis of nuclear DNA of a human-like finger bone, found in Denisova Cave in southern Siberia, points towards a complex model of migration and colonization after anatomically modern humans moved out of Africa some 50,000–60,000 years ago.

Ever since 1925, when Raymond Dart's report of the first Australopithecus skull in southern Africa upended Victorian views of human origins, there has been debate over whether our species arose only once and spread throughout the world, replacing all extant species of Homo, or whether our ancestors interbred with the other populations and subspecies. The most extreme version of the 'candelabra' model of human origins — according to which human species arose multiple times independently of our Homo ergaster ancestors — has been largely discounted.

But it has been difficult to assess more nuanced models, such as the possibility of genetic exchange with some archaic populations, including Neanderthals, and now perhaps ancient Siberians. Until recently, genetic data and interpretation of the fossil record seemed to favour a complete-replacement model, in which all human species trace all of their genetic ancestry to a single origin in one or more African populations of moderate size some 200,000 years ago2, 3, 4, 5. However, the Denisovan nuclear genome sequence, along with that of Homo neanderthalensis published by some of the same authors6, suggest that the out-of-Africa population history of Homo sapiens is probably much more intertwined than previously thought, with more intertwining in some parts of the world than others.

Read more and follow discussion at Nature.

Triangles and circles respectively represent sampling locations of Neanderthal remains and of present-day human genomes. The blue arrows indicate generally accepted major migrations of anatomically modern humans, following their departure from Africa 50,000–60,000 years ago. At this time, there were two primary archaic species in Eurasia, Neanderthals and Homo erectus; Reich, Pääbo and co-workerssuggest that a third group was also present, represented by the ancient Denisovan genome. From ancient DNA, they identify additional putative events involving two episodes of limited gene flow: first, genetic admixture from Neanderthals to modern humans, shortly after the exit from Africa; second, subsequent admixture with the archaic population exemplified by the nuclear DNA extracted from the Denisova finger bone. This second event seems to affect only the ancestors of present-day Melanesians, who are thought to have colonized Papua New Guinea some 45,000 years ago. African populations, both past and present, are genetically highly diverse, as indicated by the multiple labels.

See also "New Hominin Probably Explains Distinctiveness of Melanesians"

The Greatest Divide in Human Genealogy and History

You hear a lot of talk about the Neolithic Revolution--the gradual adoption and spread of agriculture, animal husbandry and town life by our prehistoric European ancestors--but the most important epoch in the course of civilization goes largely unnoticed in the history books. That was the abrupt shift from matriarchy and worship of the Great Goddess to the warrior-based governments and language stocks of the steppe-dwelling Indo-Aryan barbarians who invaded Old Europe beginning in the late fourth millennium BCE.

The roots of Europe's original female-oriented religion are lost in the mists of the early Stone Age, and may even precede the arrival of "modern humans" in Europe and be part of the heritage of Neanderthals. This substratum of a long-lasting peaceful hunter-gatherer society organized around the religion of the Great Goddess absorbed the spreading practice of agriculture from the Middle East beginning in the fifth millennium and reached its apogee of development in a pure form in the fourth millennium.

The cult of the Great Goddess, depicted here in an enthroned version with flanking felines from Çatal Hüyük, an 8,000-year-old shrine in present-day Turkey (p. 107), was the lifelong object of study by Lithuanian-American archeologist Marija Gimbutas, whose most influential book is The Language of the Goddess (London:  Thames & Hudson, 2006). 

The axe fell on this ancient civilization--quite literally--around 3000 BCE. As confirmed in Jane McIntosh's Handbook to Life in Prehistoric Europe (New York:  Facts on File, 2006), there was a clear line of demarcation between old and new Europe, from the Balkans to Britain, Spain and Scandinavia. The archeological record tells the story of a sweeping and abrupt end to things. The first metal weapons appear in the graves of elite males along with hoards of gold and jewels. Axes previously used to clear forests for agriculture are now battle-axes. Burials are single rather than family and clan-oriented. Whole villages were massacred and depopulated. Fortifications grew as violence escalated. The horse, venerated as just one of the totem animals of the Goddess since the early Stone Age, becomes the symbol of the warrior, along with the chariot and boat. Rock art features ithyphallic warriors wielding weapons or shooting arrows at each other. The transition can also be seen in the establishment of the Pharaohs in Egypt about 3500 BCE.

The invaders brought their male pantheon of war gods, Indo-European languages, aristocratic forms of government and Central Asian/Caucasian genes. The goddess cult underwent radical male adaptations, surviving in out-of-the-way places like Crete and Brittany. 

So, rather than one transformation, European civilization first went through a Neolithic Revolution, then conversion to warrior-dominated patriarchal societies. It can be postulated that the matriarchal societies eagerly adopted agriculture but exhausted soils, destroyed vital forests and became weaker and smaller-bodied due to a changed diet, falling prey around 3000 BCE to the barbarian warriors of the steppe, who found the accumulation of wealth and unprotected agrarian settlements of Old Europe easy pickings. Climate change could have been a contributing factor.

James Joyce called history "the nightmare from which one cannot wake." If we take a long view of human events, this nightmare began about five thousand years ago. Other-worldly religions like Christianity introduced a further element of alienation and turning away from the sources of life. Before that, people were happily alive, awake, in tune with nature and celebrated life under the auspices of matriarchy.

Assailants with bows and arrows attack

a fortified Neolithic settlement in Furfooze,

France, who defend themselves by hurling

stones and raising clubs. Reconstruction

from Louis Figuier, Primitive Man (London: 

Chatto and Windus, 1876). 

Cave of the Mare's Nest

Jewelry from the Grotte du Renne "reindeer cave" at Arcy-sur-Cure in Central France has long been assigned to Neanderthals, helping rehabilitate them in the picture paleontologists paint of early mankind. But these artifacts have now been questioned thanks to a redating of the lowest levels of the cave, where Neanderthals were presumed active. According to Science Magazine vol. 330, no. 6003, p. 439) in October 2010,

In the new study, a team led by dating expert Thomas Higham of the University of Oxford in the United Kingdom reports 31 new radiocarbon dates from the Grotte du Renne using novel methods designed to avoid contamination. The dates, obtained on materials such as bone tools and ornaments made of animal teeth, paint a disturbing picture: While upper layers attributed to modern humans clock in at no older than 35,000 years, artifacts from the Châtelperronian levels range from 21,000 years old, when Neandertals were long extinct, to 49,000 years old, before the Châtelperronian began. About one-third of the dates were outside the expected range.

What we don't understand is the dichotomy between "modern humans" and Neanderthals to begin with. If the dating was mixed (contaminated) how can paleontologists be sure, since "modern humans" and Neanderthals were mixed themselves according to all proven genetic analyses. These retests seem to be splitting hairs to prove or disprove pet theories that no longer apply.

It is particularly nonsensical to say, as the archeologist Randall White of New York University said, "This key site should be disqualified from the debate over [Neanderthal] symbolism." The debate over Neanderthals' symbolic intellectual and communicative capacities has already been settled to 99% of the scientific world's satisfaction. It is a non-issue. Paintings, jewelry and art from over 32 Neanderthal grave sites and camps settled it several years ago, and since the Neanderthal genome was sequenced in draft form earlier this year it has been demonstrated that they had the same or similar intellectual genes as "modern humans." In fact, their brains were bigger, so if anything they had a greater capacity to conceptualize the world.

We wish archeologists and science writers would work on their own symbolic thinking a bit and let the bones of tired myths and ethnocentric fallacies rest in peace. And pu-lease spell the word wrongly right. It's N-e-a-n-d-e-r-t-h-a-l. Neandertal is purist and is not going to become popular. Trust us.

Next thing you know they're going to be talking about the Visigots and Ostrogots.

We predicted as much:  anthropologists are beginning to have a more positive attitude toward the role of Neanderthals in human prehistory. According to an article in today's Washington Post, "Scientists are broadly rethinking the nature, skills and demise of the Neanderthals of Europe and Asia, steadily finding more ways that they were substantially like us and different from the limited, unchanging and ultimately doomed inferiors most commonly described in the past."

The article by Marc Kaufman is titled "Anthropologists Adopt a More Favorable View of Neanderthals," and appeared in the October 4, 2010 edition of the newspaper.

Earlier research this year noted that Europeans have, on average, 1-4% Neanderthal genes. That began the wheels of scientific thinking rolling. "Our picture of Neanderthals is likely to change radically now that we know they were among ancestors of ours, not a dead-end, primitive race," we wrote in the blog post "Most Humans Part Neanderthal" on May 12. DNA Consultants introduced its Neanderthal Index in June.

Mary Settegast is described on the jacket simply as an archeological researcher, the 20-year-old book being Plato Prehistorian; 10,000 to 5,000 B.C. Myth, Religion, Archaeology (Hudson:  Lindisfarne, 1990). It's obvious she is not a member of the entrenched academic community of archeologists and prehistorians, for she spends most of the introduction to her fascinating study inveighing against the Old Model and New Archeology and defending the value of myth. She then retells the Egyptian Priest's tale from Plato's Timaeus about how Solon's ancient Greek ancestors defeated an aggressive Atlantic sea-power situated on a now-lost continent beyond the Straits of Gilbraltar--the so-called Atlantis myth, which has no other source but the writings of Plato. Her thesis is that Plato is representing what he believed to be historical fact. Among other arguments, Settegast points out that it would have been impious for him to contrive a political fiction and put it in the mouth of Critias, who attributes the story to his grandfather, who received it from Solon himself, given the occasion of the dialogue, a celebration of Athena's festival day. She asks, "Would Socrates have Critias offer to the goddess as 'a just and truthful hymn of praise' (Timaeus 21) an intentional misrepresentation of Athena's own past history with the Greeks?"

Once Plato's word and intentions are vindicated it is possible to study the scattered clues he gives us to prehistory of the Mediterranean world in a new light. Settegast makes a good case that the Magdalenian cave art of 17,000/15,000 to 9000 BCE preserves the fading glory of an Atlantic culture of enormous power and sophistication that came to an abrupt end toward the end of the tenth millennium. She brackets the question of the location of a sunken continent and dwells instead on the blunders of modern prehistorians who fail to grasp the advanced picture of civilization left to us in Paleolithic remains like the Lascaux paintings. For instance, most anthropologists have explained the paintings as vehicles for sympathetic hunting magic without noting that it is the horse that is most commonly depicted while excavations of Magdlenian sites reveal almost exclusively the remains of reindeer as their principal animal food. The religious significance of the animals is lost on most analysts. Plato, as usual, provides the pertinent clue: the Atlantics worshipped Poseidon and regarded his sacred animal the horse with great awe. A revisionist look at the horses in cave paintings clarifies that the lines on horses' heads represent harnesses, not natural contours or anatomical details, proving that the Magdalenians or Atlantic peoples had tamed the horse by 12,000 BCE, some eight thousand years before the date assigned to the domestication of the horse in the conventional model.

 

Upper Paleolithic writing recovered from Magdalenian cave sites (top) compared to characters in three early written languages:  (b) Indus valley signs, (c) Greek and (d) Runic. Settegast (p. 28) after Forbes and Crowder, 1979.

I've just started to read the book and will conclude this "preview" for the blog by mentioning that one obstacle to accepting Plato's story at face value was that he describes the Atlantics as literate. The recent reevaluation of the "magic signs" in Magdalenian caves as a writing system with heirs in many Old World alphabets seems to bear him out once again...and make his detractors look stupid and full of hubris. It is the effect many Socratic dialogues were meant to have on their readers.

Addendum:  One of the offshoots of Atlantic Culture according to Plato Prehistorian was the Çatal Hüyük civilization that flourished in Anatolia from 6200-5300 BCE. Only 2-3 % of the 32 acre site has been excavated, but what has come to light so far includes amazing cyclopean walls, refined wall paintings and peculiar religious practices such as a vulture-bull rite, leopard shrine and Mistress of the Animals cult reminiscent of Venus figurines. It is conceivable that Atlantic Culture itself was spurred to life originally by admixture of Europeans with Neanderthals, since there are numerous signs of Neanderthal culture in  archeological remains. Significantly, the Venus figures once associated with Gravettian Culture now appear to have had their origins with Neanderthals, who occupied Europe for 350,000 years before H. sapiens sapiens. Venus figurines were worn about the neck by Neanderthals, as proved in several excavations in Spain and elsewhere. In 1961, archeologists unearthed the skull of a Neanderthal man in the ancient site of Chalcedon on the east side of the Bosporus in Asia Minor, although the find is seldom mentioned today.

Our Neanderthal Index is based on affinities with archaic populations presumed to carry the highest rate of admixture with Neanderthals. These include many of the Atlantic and Mediterranean populations mentioned in Plato Prehistorian, including Greek, Turkish, Syrian, Arabian, Basque, Egyptian and Berber.

The bombshell arrived with the May 7, 2010 issue of Science Magazine. Entitled "A Draft Sequence of the Neandertal Genome," it presented the years-long attempt of an international team of scientists to derive DNA from ancient female Neanderthal bones and determine if there was any genetic overlap with humans. The news was so sensational that the journal made the original scientific report and all collateral materials free to everyone, along with a podcast, multimedia presentation "The Neandertal Genome" and slew of links and forums for comments.

Read the original press release from the Max Planck Institute for Evolutionary Anthropology in Leipzig. It was embargoed for May 6, 2010, 8 p.m.

 

Svante Pääbo’s Neanderthal research group from left to right: Adrian Briggs, Hernán Burbano, Matthias Meyer, Anja Buchholz, Jesse Dabney, Kay Prüfer, Svante Pääbo, Janet Kelso, Tomislav Maričić, Qiaomei Fu, Udo Stenzel, Johannes Krause and Martin Kircher. (Copyright: Frank Vinken)

Some background

Discovered in a quarry in Germany in 1856, 40,000-year-old Neanderthal man became the first recognized early human fossil. The debate immediately began whether Neanderthals were a separate species or sub-species of Homo sapiens. German language orthographic reforms rendered the spelling of the name Neandertal in the twentieth century, although most people even today prefer to stick with the th of the original word. Neanderthals are named after the Neander Valley (German thal or tal) in which they first came to light.

More and more of them turned up over the years:  in Belgium (1886), a nearly complete skeleton in southern France (1908), Israel (then-Palestine, 1930) and Iraq (1953). The first ambitious genetic work was a partial sequencing of their mitochondrial DNA based on highly degraded specimens: Krings et al., Cell 90, 19 (1997). A second mitDNA sequence was achieved in 2000. The complete mtDNA sequence came in 2008:  Green et al., Cell 134, 416 (2008).

In the meantime, Neanderthals were found to have red hair and fair skin, body paint, customs, societies, rituals and art. They used fire, tools and weapons. They hunted bison, horses and other large animals and made bread of acorn meal. With their short arms and weak shoulder sockets, however, they probably could not throw spears. Before they were conquered by their smaller human cousins, they had colonized an area extending from Spain to Western Siberia and the Middle East. They were acclimated to northern Europe's icy temperatures and flourished especially before and during the last Ice Age. Then, suddenly, about 30,000 years ago, the fossil record goes silent. Their last holdout appears to have been in Spain.

Our picture of Neanderthals is likely to change radically now that we know they were among ancestors of ours, not a dead-end, primitive race. Some writers had already speculated, in fact, that Neanderthals were more advanced in many ways than their rivals, Cro-Magnon Man. Certainly, their religion was highly adumbrated. Some carried Venus figures on necklaces. According to the author of The Neanderthal's Necklace, Juan Luis Arsuaga (co-director of the World Heritage Site Sierra de Atapuerca in Spain), at one burial in Russia, a 60-year-old adult had 3,000 beads of drilled mammoth ivory sewn onto his clothes. A boy in the same burial wore a belt decorated with 250 arctic fox canines. There were also shells, armbands, head ornaments, bracelets, pendants, assegais, ceremonial staffs and other artifacts made of bone, antler, ivory and stone (p. 294).

The blockbuster draft of the Neanderthal genome just published noted genes linked to cognitive abilities, geo-spatial skills, language and motor coordination as well as strength, reproductive advantages and (what we knew already) cold adaptation. Much attention is likely to focus on the Neanderthal's signature occipital bun, noticed in isolated or vestigial populations like the Berbers, Saami, Canary Islands, Native Americans, Australian Aborigines and Melungeons. These populations probably preserved greater proportions of Neanderthal admixture than others.

Because the genetic legacy of Neanderthals (so far) has not been detected in the mitochondrial record, it is believed that gene flow came from males mating with human females. No male Neanderthal lines survive -- not surprisingly. Only autosomal DNA reveals the Neanderthal contribution to human populations.